Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5392906..5393531 Replicon chromosome
Accession NZ_CP095264
Organism Klebsiella pneumoniae strain 21091025

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag MU321_RS26645 Protein ID WP_002882817.1
Coordinates 5392906..5393289 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag MU321_RS26650 Protein ID WP_004150355.1
Coordinates 5393289..5393531 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU321_RS26630 (MU321_26630) 5390272..5391174 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
MU321_RS26635 (MU321_26635) 5391171..5391806 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
MU321_RS26640 (MU321_26640) 5391803..5392732 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
MU321_RS26645 (MU321_26645) 5392906..5393289 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
MU321_RS26650 (MU321_26650) 5393289..5393531 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
MU321_RS26655 (MU321_26655) 5393736..5394653 + 918 WP_002882812.1 alpha/beta hydrolase -
MU321_RS26660 (MU321_26660) 5394667..5395608 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
MU321_RS26665 (MU321_26665) 5395653..5396090 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
MU321_RS26670 (MU321_26670) 5396087..5396947 - 861 WP_002882807.1 virulence factor BrkB family protein -
MU321_RS26675 (MU321_26675) 5396941..5397540 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T241826 WP_002882817.1 NZ_CP095264:c5393289-5392906 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T241826 NZ_OU342919:2554820-2555227 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT241826 WP_004150355.1 NZ_CP095264:c5393531-5393289 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT241826 NZ_OU342919:2554573-2554839 [Escherichia coli]
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References