Detailed information of TA system TA241824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4912671..4913187
• Replicon: chromosome
• Accession: NZ_CP095264
• Organism: Klebsiella pneumoniae strain 21091025

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J2XDK6
• Locus tag: MU321_RS24340
• Protein ID: WP_002886902.1
• Coordinates: 4912671..4912955 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: MU321_RS24345
• Protein ID: WP_002886901.1
• Coordinates: 4912945..4913187 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU321_RS24315 (MU321_24315)	4908155..4908418	-	264	WP_004152271.1	PTS sugar transporter subunit IIB	-
MU321_RS24320 (MU321_24320)	4908548..4908721	+	174	WP_002886906.1	hypothetical protein	-
MU321_RS24325 (MU321_24325)	4908724..4909467	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
MU321_RS24330 (MU321_24330)	4909824..4911962	+	2139	WP_002886904.1	anaerobic ribonucleoside-triphosphate reductase	-
MU321_RS24335 (MU321_24335)	4912203..4912667	+	465	WP_002886903.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
MU321_RS24340 (MU321_24340)	4912671..4912955	-	285	WP_002886902.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MU321_RS24345 (MU321_24345)	4912945..4913187	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MU321_RS24350 (MU321_24350)	4913265..4915175	-	1911	WP_004152270.1	PRD domain-containing protein	-
MU321_RS24355 (MU321_24355)	4915198..4916352	-	1155	WP_002886900.1	lactonase family protein	-
MU321_RS24360 (MU321_24360)	4916418..4917158	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11125.95 Da
• Isoelectric Point: 10.3787

>T241824 WP_002886902.1 NZ_CP095264:c4912955-4912671 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T241824 NZ_OU342919:1984975-1985502 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT241824 WP_002886901.1 NZ_CP095264:c4913187-4912945 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT241824 NZ_OU342919:1984702-1984968 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3GMH2

Antitoxin

• AlphaFold DB: A0A0H3GLP0