241821

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2734807..2736395 Replicon chromosome
Accession NZ_CP095264
Organism Klebsiella pneumoniae strain 21091025

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag MU321_RS13555 Protein ID WP_004199851.1
Coordinates 2734807..2736129 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag MU321_RS13560 Protein ID WP_002904790.1
Coordinates 2736129..2736395 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU321_RS13540 (MU321_13540) 2729872..2732373 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
MU321_RS13545 (MU321_13545) 2732361..2733365 + 1005 WP_004199852.1 fimbrial protein -
MU321_RS13550 (MU321_13550) 2733498..2734790 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
MU321_RS13555 (MU321_13555) 2734807..2736129 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
MU321_RS13560 (MU321_13560) 2736129..2736395 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MU321_RS13565 (MU321_13565) 2736661..2736987 - 327 WP_002904788.1 hydroxyisourate hydrolase -
MU321_RS13570 (MU321_13570) 2736984..2737484 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
MU321_RS13575 (MU321_13575) 2737462..2738841 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
MU321_RS13580 (MU321_13580) 2739187..2740341 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
MU321_RS13585 (MU321_13585) 2740322..2741245 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T241821 WP_004199851.1 NZ_CP095264:c2736129-2734807 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T241821 NZ_OU342919:c1215843-1215670 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT241821 WP_002904790.1 NZ_CP095264:c2736395-2736129 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT241821 NZ_OU342919:c1216167-1215871 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References