Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 879799..880453 Replicon chromosome
Accession NZ_CP095264
Organism Klebsiella pneumoniae strain 21091025

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag MU321_RS04440 Protein ID WP_004144731.1
Coordinates 880046..880453 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MU321_RS04435 Protein ID WP_002916312.1
Coordinates 879799..880065 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU321_RS04410 (MU321_04410) 874955..876388 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MU321_RS04415 (MU321_04415) 876507..877235 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MU321_RS04420 (MU321_04420) 877285..877596 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MU321_RS04425 (MU321_04425) 877760..878419 + 660 WP_002916317.1 hemolysin III family protein -
MU321_RS04430 (MU321_04430) 878570..879553 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MU321_RS04435 (MU321_04435) 879799..880065 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MU321_RS04440 (MU321_04440) 880046..880453 + 408 WP_004144731.1 protein YgfX Toxin
MU321_RS04445 (MU321_04445) 880460..880981 - 522 WP_002916308.1 flavodoxin FldB -
MU321_RS04450 (MU321_04450) 881082..881978 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MU321_RS04455 (MU321_04455) 882001..882714 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MU321_RS04460 (MU321_04460) 882720..884453 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T241812 WP_004144731.1 NZ_CP095264:880046-880453 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T241812 NZ_OU342706:c4958802-4958419 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT241812 WP_002916312.1 NZ_CP095264:879799-880065 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241812 NZ_OU342706:c4959044-4958802 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References