Detailed information of TA system TA024180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1172390..1172868
• Replicon: chromosome
• Accession: NC_013008
• Organism: Escherichia coli O157:H7 str. TW14359

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: ECSP_RS05590
• Protein ID: WP_001303876.1
• Coordinates: 1172390..1172677 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: ECSP_RS05595
• Protein ID: WP_000536233.1
• Coordinates: 1172677..1172868 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECSP_RS05555	1167539..1170010	-	2472	WP_000034474.1	exonuclease	-
ECSP_RS05560	1170104..1170295	-	192	WP_001098307.1	DUF1482 family protein	-
ECSP_RS31830	1170292..1170480	-	189	WP_000413705.1	cell division inhibition protein DicB	-
ECSP_RS05575	1171054..1171239	+	186	WP_001133046.1	hypothetical protein	-
ECSP_RS05580	1171426..1171815	-	390	WP_000394511.1	hypothetical protein	-
ECSP_RS05585	1171957..1172112	-	156	WP_000379575.1	DUF1391 family protein	-
ECSP_RS05590	1172390..1172677	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ECSP_RS05595	1172677..1172868	-	192	WP_000536233.1	hypothetical protein	Antitoxin
ECSP_RS05600	1172896..1173297	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
ECSP_RS05605	1173406..1173678	+	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
ECSP_RS05610	1173662..1174087	+	426	WP_000693855.1	Rha family transcriptional regulator	-
ECSP_RS31845	1174294..1174749	-	456	WP_000273724.1	hypothetical protein	-
ECSP_RS05620	1174828..1175925	+	1098	WP_001475117.1	hypothetical protein	-
ECSP_RS05625	1175932..1176678	+	747	WP_000788745.1	ATP-binding protein	-
ECSP_RS05630	1176700..1177470	+	771	WP_000450992.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T24180 WP_001303876.1 NC_013008:c1172677-1172390 [Escherichia coli O157:H7 str. TW14359]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T24180 NC_013008:c1172677-1172390 [Escherichia coli O157:H7 str. TW14359]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT24180 WP_000536233.1 NC_013008:c1172868-1172677 [Escherichia coli O157:H7 str. TW14359]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT24180 NC_013008:c1172868-1172677 [Escherichia coli O157:H7 str. TW14359]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA