Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1006023..1006728 Replicon chromosome
Accession NC_013008
Organism Escherichia coli O157:H7 str. TW14359

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag ECSP_RS04815 Protein ID WP_000539519.1
Coordinates 1006342..1006728 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ECSP_RS04810 Protein ID WP_001280945.1
Coordinates 1006023..1006352 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECSP_RS04795 1001180..1002091 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
ECSP_RS04800 1002269..1004617 + 2349 WP_000950320.1 EAL domain-containing protein -
ECSP_RS04805 1004625..1005953 + 1329 WP_000086905.1 GGDEF domain-containing protein -
ECSP_RS04810 1006023..1006352 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
ECSP_RS04815 1006342..1006728 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECSP_RS04820 1006954..1008279 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
ECSP_RS04825 1008492..1008875 + 384 WP_000497137.1 biofilm formation regulator BssR -
ECSP_RS04830 1008986..1010101 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
ECSP_RS04835 1010098..1010724 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T24179 WP_000539519.1 NC_013008:c1006728-1006342 [Escherichia coli O157:H7 str. TW14359]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T24179 NC_013008:c1006728-1006342 [Escherichia coli O157:H7 str. TW14359]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT24179 WP_001280945.1 NC_013008:c1006352-1006023 [Escherichia coli O157:H7 str. TW14359]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT24179 NC_013008:c1006352-1006023 [Escherichia coli O157:H7 str. TW14359]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References