Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3238174..3238828 Replicon chromosome
Accession NZ_CP095253
Organism Klebsiella pneumoniae strain 21080937

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag MU320_RS15860 Protein ID WP_004144731.1
Coordinates 3238421..3238828 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MU320_RS15855 Protein ID WP_002916312.1
Coordinates 3238174..3238440 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU320_RS15830 (MU320_15830) 3233330..3234763 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MU320_RS15835 (MU320_15835) 3234882..3235610 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MU320_RS15840 (MU320_15840) 3235660..3235971 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MU320_RS15845 (MU320_15845) 3236135..3236794 + 660 WP_002916317.1 hemolysin III family protein -
MU320_RS15850 (MU320_15850) 3236945..3237928 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MU320_RS15855 (MU320_15855) 3238174..3238440 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MU320_RS15860 (MU320_15860) 3238421..3238828 + 408 WP_004144731.1 protein YgfX Toxin
MU320_RS15865 (MU320_15865) 3238835..3239356 - 522 WP_002916308.1 flavodoxin FldB -
MU320_RS15870 (MU320_15870) 3239457..3240353 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MU320_RS15875 (MU320_15875) 3240376..3241089 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MU320_RS15880 (MU320_15880) 3241095..3242828 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T241789 WP_004144731.1 NZ_CP095253:3238421-3238828 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T241789 NZ_OU015947:48924-49274 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTAAAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT241789 WP_002916312.1 NZ_CP095253:3238174-3238440 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241789 NZ_OU015947:48667-48930 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References