Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1799170..1799686 Replicon chromosome
Accession NZ_CP095253
Organism Klebsiella pneumoniae strain 21080937

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MU320_RS08745 Protein ID WP_002886902.1
Coordinates 1799170..1799454 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MU320_RS08750 Protein ID WP_002886901.1
Coordinates 1799444..1799686 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU320_RS08720 (MU320_08720) 1794654..1794962 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
MU320_RS08725 (MU320_08725) 1795047..1795220 + 174 WP_002886906.1 hypothetical protein -
MU320_RS08730 (MU320_08730) 1795223..1795966 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MU320_RS08735 (MU320_08735) 1796323..1798461 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MU320_RS08740 (MU320_08740) 1798702..1799166 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MU320_RS08745 (MU320_08745) 1799170..1799454 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU320_RS08750 (MU320_08750) 1799444..1799686 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MU320_RS08755 (MU320_08755) 1799764..1801674 - 1911 WP_004152270.1 PRD domain-containing protein -
MU320_RS08760 (MU320_08760) 1801697..1802851 - 1155 WP_002886900.1 lactonase family protein -
MU320_RS08765 (MU320_08765) 1802917..1803657 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T241783 WP_002886902.1 NZ_CP095253:c1799454-1799170 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241783 NZ_OU015708:201724-201990 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241783 WP_002886901.1 NZ_CP095253:c1799686-1799444 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241783 NZ_OU015708:201461-201724 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References