Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1696527..1697337 Replicon chromosome
Accession NZ_CP095253
Organism Klebsiella pneumoniae strain 21080937

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag MU320_RS08265 Protein ID WP_002887280.1
Coordinates 1696527..1697060 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag MU320_RS08270 Protein ID WP_002887278.1
Coordinates 1697071..1697337 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU320_RS08260 (MU320_08260) 1695358..1696479 + 1122 WP_002887282.1 cupin domain-containing protein -
MU320_RS08265 (MU320_08265) 1696527..1697060 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
MU320_RS08270 (MU320_08270) 1697071..1697337 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
MU320_RS08275 (MU320_08275) 1697440..1698873 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
MU320_RS08280 (MU320_08280) 1698863..1699546 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
MU320_RS08285 (MU320_08285) 1699718..1701103 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
MU320_RS08290 (MU320_08290) 1701121..1701465 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T241782 WP_002887280.1 NZ_CP095253:c1697060-1696527 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T241782 NZ_OU015584:2835089-2835370 [Parvicella tangerina]
ATGAGCACTACAAAATTTAATATAGCAGATTATTTAGATGACAATGAAATGATTGTTGAGTATTTAAACAACATTTTGGA
AGAAGGCGATTCTTCTGATATTATTTCCGCAATTGGTCACGTTGCGAAAGCAATTGGAATGACTAAAATTGCTGAAGATA
CAGGTATGAGCCGACCTAGCTTATACAAAGCACTTTCTGAAAACTCTAAACCTCAGTTTGAAACTATTCTCAAAGTTCTC
AGAGCCATCGGAGGTAATATACAGATCAACCCAGCAGCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT241782 WP_002887278.1 NZ_CP095253:c1697337-1697071 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT241782 NZ_OU015584:2834790-2835089 [Parvicella tangerina]
ATGTATATAATTGAAAAGACTCCTGAATTTGATAAGTGGTTGAGGAAACTCAAGGACAGAAGAGCTAAAGCTAAAATCTT
ATTCAGGATTCAAAGAATTGAGGAGCAAGGAAATTTTGGAGACTGTCAACCAATAGGAGAAGGACTAAGCGAATTGAGAA
TTCACTATGCAAAAGGTTACCGAGTATATATTAAAGAATATAGCGGAACCATTGTAATTCTTCTGAATGGAGGTGATAAA
TCAACTCAGTCAAAAGATATTGCAAAAGCAAAAGATTTATGGACGAAATACAAGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References