Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1080233..1080852 Replicon chromosome
Accession NZ_CP095253
Organism Klebsiella pneumoniae strain 21080937

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MU320_RS05300 Protein ID WP_002892050.1
Coordinates 1080634..1080852 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MU320_RS05295 Protein ID WP_002892066.1
Coordinates 1080233..1080607 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU320_RS05285 (MU320_05285) 1075385..1076578 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MU320_RS05290 (MU320_05290) 1076601..1079747 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
MU320_RS05295 (MU320_05295) 1080233..1080607 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MU320_RS05300 (MU320_05300) 1080634..1080852 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MU320_RS05305 (MU320_05305) 1081011..1081577 + 567 WP_002892030.1 maltose O-acetyltransferase -
MU320_RS05310 (MU320_05310) 1081549..1081689 - 141 WP_004147370.1 hypothetical protein -
MU320_RS05315 (MU320_05315) 1081710..1082180 + 471 WP_002892026.1 YlaC family protein -
MU320_RS05320 (MU320_05320) 1082155..1083606 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
MU320_RS05325 (MU320_05325) 1083707..1084405 + 699 WP_002892021.1 GNAT family protein -
MU320_RS05330 (MU320_05330) 1084402..1084542 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MU320_RS05335 (MU320_05335) 1084542..1084805 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T241781 WP_002892050.1 NZ_CP095253:1080634-1080852 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T241781 NZ_OU015584:2834790-2835089 [Parvicella tangerina]
ATGTATATAATTGAAAAGACTCCTGAATTTGATAAGTGGTTGAGGAAACTCAAGGACAGAAGAGCTAAAGCTAAAATCTT
ATTCAGGATTCAAAGAATTGAGGAGCAAGGAAATTTTGGAGACTGTCAACCAATAGGAGAAGGACTAAGCGAATTGAGAA
TTCACTATGCAAAAGGTTACCGAGTATATATTAAAGAATATAGCGGAACCATTGTAATTCTTCTGAATGGAGGTGATAAA
TCAACTCAGTCAAAAGATATTGCAAAAGCAAAAGATTTATGGACGAAATACAAGAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT241781 WP_002892066.1 NZ_CP095253:1080233-1080607 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT241781 NZ_OU015584:2835089-2835370 [Parvicella tangerina]
ATGAGCACTACAAAATTTAATATAGCAGATTATTTAGATGACAATGAAATGATTGTTGAGTATTTAAACAACATTTTGGA
AGAAGGCGATTCTTCTGATATTATTTCCGCAATTGGTCACGTTGCGAAAGCAATTGGAATGACTAAAATTGCTGAAGATA
CAGGTATGAGCCGACCTAGCTTATACAAAGCACTTTCTGAAAACTCTAAACCTCAGTTTGAAACTATTCTCAAAGTTCTC
AGAGCCATCGGAGGTAATATACAGATCAACCCAGCAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References