Detailed information of TA system TA241780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 490..964
• Replicon: plasmid p21080534_5
• Accession: NZ_CP095252
• Organism: Klebsiella pneumoniae strain 21080534

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: A0A8J3DT22
• Locus tag: MU311_RS28840
• Protein ID: WP_004197762.1
• Coordinates: 698..964 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: S1EJF5
• Locus tag: MU311_RS28835
• Protein ID: WP_000879771.1
• Coordinates: 490..714 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU311_RS28835 (MU311_28835)	490..714	+	225	WP_000879771.1	DUF6290 family protein	Antitoxin
MU311_RS28840 (MU311_28840)	698..964	+	267	WP_004197762.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MU311_RS28845 (MU311_28845)	1034..1384	-	351	WP_004197756.1	hypothetical protein	-
MU311_RS28850 (MU311_28850)	1450..1995	-	546	WP_023317533.1	hypothetical protein	-
MU311_RS28855 (MU311_28855)	2021..2347	-	327	WP_050516389.1	hypothetical protein	-
MU311_RS28860 (MU311_28860)	3503..3679	+	177	WP_004197757.1	hypothetical protein	-
MU311_RS28865 (MU311_28865)	3669..4013	+	345	WP_062955149.1	MobC family plasmid mobilization relaxosome protein	-
MU311_RS28870 (MU311_28870)	4222..4656	+	435	Protein_7	relaxase/mobilization nuclease domain-containing protein	-
MU311_RS28875 (MU311_28875)	4691..5200	+	510	WP_032433972.1	MbeB family mobilization protein	-
MU311_RS28880 (MU311_28880)	5207..5419	+	213	WP_021527181.1	MbeD family mobilization/exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..5596	5596

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Relaxosome protein TraY (4-45)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10342.96 Da
• Isoelectric Point: 9.8727

>T241780 WP_004197762.1 NZ_CP095252:698-964 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Nucleotide

• Length: 267 bp

>T241780 NZ_CP095252:698-964 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8369.28 Da
• Isoelectric Point: 4.6533

>AT241780 WP_000879771.1 NZ_CP095252:490-714 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Nucleotide

• Length: 225 bp

>AT241780 NZ_CP095252:490-714 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Structures

Antitoxin

• AlphaFold DB: S1EJF5