Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4863613..4864129 Replicon chromosome
Accession NZ_CP095247
Organism Klebsiella pneumoniae strain 21080534

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MU311_RS24165 Protein ID WP_002886902.1
Coordinates 4863613..4863897 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MU311_RS24170 Protein ID WP_002886901.1
Coordinates 4863887..4864129 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU311_RS24140 (MU311_24140) 4859097..4859360 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
MU311_RS24145 (MU311_24145) 4859490..4859663 + 174 WP_002886906.1 hypothetical protein -
MU311_RS24150 (MU311_24150) 4859666..4860409 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MU311_RS24155 (MU311_24155) 4860766..4862904 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MU311_RS24160 (MU311_24160) 4863145..4863609 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MU311_RS24165 (MU311_24165) 4863613..4863897 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU311_RS24170 (MU311_24170) 4863887..4864129 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MU311_RS24175 (MU311_24175) 4864207..4866117 - 1911 WP_004152270.1 PRD domain-containing protein -
MU311_RS24180 (MU311_24180) 4866140..4867294 - 1155 WP_002886900.1 lactonase family protein -
MU311_RS24185 (MU311_24185) 4867360..4868100 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T241767 WP_002886902.1 NZ_CP095247:c4863897-4863613 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241767 NZ_OU015342:c4229998-4229714 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241767 WP_002886901.1 NZ_CP095247:c4864129-4863887 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241767 NZ_OU015342:c4230230-4229988 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References