Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 879434..880088 Replicon chromosome
Accession NZ_CP095247
Organism Klebsiella pneumoniae strain 21080534

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag MU311_RS04445 Protein ID WP_004144731.1
Coordinates 879681..880088 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MU311_RS04440 Protein ID WP_002916312.1
Coordinates 879434..879700 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU311_RS04415 (MU311_04415) 874590..876023 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MU311_RS04420 (MU311_04420) 876142..876870 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MU311_RS04425 (MU311_04425) 876920..877231 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MU311_RS04430 (MU311_04430) 877395..878054 + 660 WP_002916317.1 hemolysin III family protein -
MU311_RS04435 (MU311_04435) 878205..879188 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MU311_RS04440 (MU311_04440) 879434..879700 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MU311_RS04445 (MU311_04445) 879681..880088 + 408 WP_004144731.1 protein YgfX Toxin
MU311_RS04450 (MU311_04450) 880095..880616 - 522 WP_002916308.1 flavodoxin FldB -
MU311_RS04455 (MU311_04455) 880717..881613 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MU311_RS04460 (MU311_04460) 881636..882349 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MU311_RS04465 (MU311_04465) 882355..884088 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T241755 WP_004144731.1 NZ_CP095247:879681-880088 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T241755 NZ_OU015341:c14266-13916 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT241755 WP_002916312.1 NZ_CP095247:879434-879700 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241755 NZ_OU015341:c13911-13609 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References