Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 55341..56251 | Replicon | plasmid p21080237_1 |
| Accession | NZ_CP095241 | ||
| Organism | Klebsiella pneumoniae strain 21080237 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | MU300_RS26790 | Protein ID | WP_004026354.1 |
| Coordinates | 55341..55811 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | MU300_RS26795 | Protein ID | WP_004026357.1 |
| Coordinates | 55808..56251 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MU300_RS26750 (MU300_26745) | 50657..50971 | + | 315 | WP_011251273.1 | hypothetical protein | - |
| MU300_RS26755 (MU300_26750) | 50980..51474 | + | 495 | WP_011251274.1 | hypothetical protein | - |
| MU300_RS26760 (MU300_26755) | 51480..51920 | + | 441 | WP_011251275.1 | hypothetical protein | - |
| MU300_RS26765 (MU300_26760) | 52345..53301 | - | 957 | WP_011251280.1 | DsbA family protein | - |
| MU300_RS26770 (MU300_26765) | 53361..53702 | - | 342 | WP_011251281.1 | hypothetical protein | - |
| MU300_RS26775 (MU300_26770) | 53716..54027 | - | 312 | WP_011251282.1 | hypothetical protein | - |
| MU300_RS26780 (MU300_26775) | 54044..54493 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| MU300_RS26790 (MU300_26785) | 55341..55811 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| MU300_RS26795 (MU300_26790) | 55808..56251 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| MU300_RS26800 (MU300_26795) | 56352..56855 | - | 504 | Protein_65 | DUF4113 domain-containing protein | - |
| MU300_RS26805 (MU300_26800) | 57061..58041 | - | 981 | WP_000019445.1 | IS5-like element ISKpn26 family transposase | - |
| MU300_RS26810 (MU300_26805) | 58107..59414 | + | 1308 | Protein_67 | FepA family TonB-dependent siderophore receptor | - |
| MU300_RS26815 (MU300_26810) | 59476..59697 | + | 222 | WP_004213615.1 | hypothetical protein | - |
| MU300_RS26820 (MU300_26815) | 59840..60742 | - | 903 | WP_004213613.1 | DMT family inner membrane transporter PEG344 | - |
| MU300_RS26825 (MU300_26820) | 60815..61216 | - | 402 | WP_214588034.1 | LuxR C-terminal-related transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..188001 | 188001 | |
| - | inside | IScluster/Tn | - | iroN / rmpA | 49060..69036 | 19976 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T241745 WP_004026354.1 NZ_CP095241:c55811-55341 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T241745 NZ_OU015340:c2494044-2493760 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT241745 WP_004026357.1 NZ_CP095241:c56251-55808 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT241745 NZ_OU015340:c2494276-2494034 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |