241743

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4310719..4311338 Replicon chromosome
Accession NZ_CP095240
Organism Klebsiella pneumoniae strain 21080237

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MU300_RS21155 Protein ID WP_002892050.1
Coordinates 4310719..4310937 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MU300_RS21160 Protein ID WP_002892066.1
Coordinates 4310964..4311338 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU300_RS21120 (MU300_21115) 4306766..4307029 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
MU300_RS21125 (MU300_21120) 4307029..4307169 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MU300_RS21130 (MU300_21125) 4307166..4307864 - 699 WP_002892021.1 GNAT family protein -
MU300_RS21135 (MU300_21130) 4307965..4309416 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
MU300_RS21140 (MU300_21135) 4309391..4309861 - 471 WP_002892026.1 YlaC family protein -
MU300_RS21145 (MU300_21140) 4309882..4310022 + 141 WP_004147370.1 hypothetical protein -
MU300_RS21150 (MU300_21145) 4309994..4310560 - 567 WP_002892030.1 maltose O-acetyltransferase -
MU300_RS21155 (MU300_21150) 4310719..4310937 - 219 WP_002892050.1 HHA domain-containing protein Toxin
MU300_RS21160 (MU300_21155) 4310964..4311338 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MU300_RS21165 (MU300_21160) 4311824..4314970 - 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
MU300_RS21170 (MU300_21165) 4314993..4316186 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T241743 WP_002892050.1 NZ_CP095240:c4310937-4310719 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T241743 NZ_OU015340:1986806-1987081 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT241743 WP_002892066.1 NZ_CP095240:c4311338-4310964 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT241743 NZ_OU015340:c1987071-1986649 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References