Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3592973..3593489 Replicon chromosome
Accession NZ_CP095240
Organism Klebsiella pneumoniae strain 21080237

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MU300_RS17715 Protein ID WP_002886902.1
Coordinates 3593205..3593489 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MU300_RS17710 Protein ID WP_002886901.1
Coordinates 3592973..3593215 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU300_RS17695 (MU300_17690) 3589002..3589742 + 741 WP_002886899.1 KDGP aldolase family protein -
MU300_RS17700 (MU300_17695) 3589808..3590962 + 1155 WP_002886900.1 lactonase family protein -
MU300_RS17705 (MU300_17700) 3590985..3592895 + 1911 WP_004152270.1 PRD domain-containing protein -
MU300_RS17710 (MU300_17705) 3592973..3593215 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MU300_RS17715 (MU300_17710) 3593205..3593489 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU300_RS17720 (MU300_17715) 3593493..3593957 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MU300_RS17725 (MU300_17720) 3594198..3596336 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MU300_RS17730 (MU300_17725) 3596693..3597436 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MU300_RS17735 (MU300_17730) 3597439..3597612 - 174 WP_002886906.1 hypothetical protein -
MU300_RS17740 (MU300_17735) 3597742..3598005 + 264 WP_004152271.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T241741 WP_002886902.1 NZ_CP095240:3593205-3593489 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241741 NZ_OU015340:335502-335605 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241741 WP_002886901.1 NZ_CP095240:3592973-3593215 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241741 NZ_OU015340:c335607-335462 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References