241735

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2150768..2151422 Replicon chromosome
Accession NZ_CP095240
Organism Klebsiella pneumoniae strain 21080237

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag MU300_RS10585 Protein ID WP_004144731.1
Coordinates 2150768..2151175 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MU300_RS10590 Protein ID WP_002916312.1
Coordinates 2151156..2151422 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU300_RS10565 (MU300_10560) 2146768..2148501 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
MU300_RS10570 (MU300_10565) 2148507..2149220 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MU300_RS10575 (MU300_10570) 2149243..2150139 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MU300_RS10580 (MU300_10575) 2150240..2150761 + 522 WP_002916308.1 flavodoxin FldB -
MU300_RS10585 (MU300_10580) 2150768..2151175 - 408 WP_004144731.1 protein YgfX Toxin
MU300_RS10590 (MU300_10585) 2151156..2151422 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MU300_RS10595 (MU300_10590) 2151668..2152651 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MU300_RS10600 (MU300_10595) 2152802..2153461 - 660 WP_002916317.1 hemolysin III family protein -
MU300_RS10605 (MU300_10600) 2153625..2153936 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MU300_RS10610 (MU300_10605) 2153986..2154714 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MU300_RS10615 (MU300_10610) 2154833..2156266 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T241735 WP_004144731.1 NZ_CP095240:c2151175-2150768 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T241735 NZ_OU015323:3570093-3570461 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT241735 WP_002916312.1 NZ_CP095240:c2151422-2151156 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241735 NZ_OU015323:3569875-3570096 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References