Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2528..3002 Replicon plasmid p21072329_5
Accession NZ_CP095239
Organism Klebsiella pneumoniae strain 21072329

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag MU289_RS28825 Protein ID WP_004197762.1
Coordinates 2528..2794 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag MU289_RS28830 Protein ID WP_000879771.1
Coordinates 2778..3002 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU289_RS28810 (MU289_28810) 1145..1471 + 327 WP_050516389.1 hypothetical protein -
MU289_RS28815 (MU289_28815) 1497..2042 + 546 WP_023317533.1 hypothetical protein -
MU289_RS28820 (MU289_28820) 2108..2458 + 351 WP_004197756.1 hypothetical protein -
MU289_RS28825 (MU289_28825) 2528..2794 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU289_RS28830 (MU289_28830) 2778..3002 - 225 WP_000879771.1 DUF6290 family protein Antitoxin
MU289_RS28835 (MU289_28835) 3669..3881 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
MU289_RS28840 (MU289_28840) 3888..4397 - 510 WP_032433972.1 MbeB family mobilization protein -
MU289_RS28845 (MU289_28845) 4432..4866 - 435 Protein_7 relaxase/mobilization nuclease domain-containing protein -
MU289_RS28850 (MU289_28850) 5075..5419 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
MU289_RS28855 (MU289_28855) 5409..5585 - 177 WP_004197757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T241725 WP_004197762.1 NZ_CP095239:c2794-2528 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

>T241725 NZ_OU015323:335501-335604 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT241725 WP_000879771.1 NZ_CP095239:c3002-2778 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp

>AT241725 NZ_OU015323:c335606-335461 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References