Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3230153..3230807 Replicon chromosome
Accession NZ_CP095234
Organism Klebsiella pneumoniae strain 21072329

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag MU289_RS15820 Protein ID WP_004144731.1
Coordinates 3230400..3230807 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MU289_RS15815 Protein ID WP_002916312.1
Coordinates 3230153..3230419 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU289_RS15790 (MU289_15790) 3225309..3226742 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MU289_RS15795 (MU289_15795) 3226861..3227589 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MU289_RS15800 (MU289_15800) 3227639..3227950 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MU289_RS15805 (MU289_15805) 3228114..3228773 + 660 WP_002916317.1 hemolysin III family protein -
MU289_RS15810 (MU289_15810) 3228924..3229907 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MU289_RS15815 (MU289_15815) 3230153..3230419 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MU289_RS15820 (MU289_15820) 3230400..3230807 + 408 WP_004144731.1 protein YgfX Toxin
MU289_RS15825 (MU289_15825) 3230814..3231335 - 522 WP_002916308.1 flavodoxin FldB -
MU289_RS15830 (MU289_15830) 3231436..3232332 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MU289_RS15835 (MU289_15835) 3232355..3233068 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MU289_RS15840 (MU289_15840) 3233074..3234807 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T241709 WP_004144731.1 NZ_CP095234:3230400-3230807 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T241709 NZ_OD940437:c2612388-2612287 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT241709 WP_002916312.1 NZ_CP095234:3230153-3230419 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241709 NZ_OD940437:2612164-2612342 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References