Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1791972..1792488 Replicon chromosome
Accession NZ_CP095234
Organism Klebsiella pneumoniae strain 21072329

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MU289_RS08700 Protein ID WP_002886902.1
Coordinates 1791972..1792256 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MU289_RS08705 Protein ID WP_002886901.1
Coordinates 1792246..1792488 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU289_RS08675 (MU289_08675) 1787456..1787719 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
MU289_RS08680 (MU289_08680) 1787849..1788022 + 174 WP_002886906.1 hypothetical protein -
MU289_RS08685 (MU289_08685) 1788025..1788768 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MU289_RS08690 (MU289_08690) 1789125..1791263 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MU289_RS08695 (MU289_08695) 1791504..1791968 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MU289_RS08700 (MU289_08700) 1791972..1792256 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU289_RS08705 (MU289_08705) 1792246..1792488 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MU289_RS08710 (MU289_08710) 1792566..1794476 - 1911 WP_004152270.1 PRD domain-containing protein -
MU289_RS08715 (MU289_08715) 1794499..1795653 - 1155 WP_002886900.1 lactonase family protein -
MU289_RS08720 (MU289_08720) 1795719..1796459 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T241703 WP_002886902.1 NZ_CP095234:c1792256-1791972 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241703 NZ_OD940434:2697149-2697298 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGTGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241703 WP_002886901.1 NZ_CP095234:c1792488-1792246 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241703 NZ_OD940434:c2697486-2697231 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATAAT
GGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTGACCTTTTTAGTTACAAAA
AATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCACAATCAAAGCA
ATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References