Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1075488..1076107 Replicon chromosome
Accession NZ_CP095234
Organism Klebsiella pneumoniae strain 21072329

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MU289_RS05265 Protein ID WP_002892050.1
Coordinates 1075889..1076107 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MU289_RS05260 Protein ID WP_002892066.1
Coordinates 1075488..1075862 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU289_RS05250 (MU289_05250) 1070640..1071833 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MU289_RS05255 (MU289_05255) 1071856..1075002 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
MU289_RS05260 (MU289_05260) 1075488..1075862 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MU289_RS05265 (MU289_05265) 1075889..1076107 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MU289_RS05270 (MU289_05270) 1076266..1076832 + 567 WP_002892030.1 maltose O-acetyltransferase -
MU289_RS05275 (MU289_05275) 1076804..1076944 - 141 WP_004147370.1 hypothetical protein -
MU289_RS05280 (MU289_05280) 1076965..1077435 + 471 WP_002892026.1 YlaC family protein -
MU289_RS05285 (MU289_05285) 1077410..1078861 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
MU289_RS05290 (MU289_05290) 1078962..1079660 + 699 WP_002892021.1 GNAT family protein -
MU289_RS05295 (MU289_05295) 1079657..1079797 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MU289_RS05300 (MU289_05300) 1079797..1080060 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T241701 WP_002892050.1 NZ_CP095234:1075889-1076107 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T241701 NZ_OD940434:c2548975-2548874 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT241701 WP_002892066.1 NZ_CP095234:1075488-1075862 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT241701 NZ_OD940434:2548752-2548929 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References