Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 3776527..3776939 Replicon chromosome
Accession NZ_CP095187
Organism Pseudoxanthomonas sp. F37

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MUU77_RS17595 Protein ID WP_245089684.1
Coordinates 3776745..3776939 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MUU77_RS17590 Protein ID WP_245089681.1
Coordinates 3776527..3776739 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUU77_RS17550 (MUU77_17550) 3771528..3772481 - 954 WP_245089665.1 HPP family protein -
MUU77_RS17555 (MUU77_17555) 3772643..3773314 + 672 WP_187574066.1 Fe2+-dependent dioxygenase -
MUU77_RS17560 (MUU77_17560) 3773360..3773677 - 318 WP_245089667.1 DUF3817 domain-containing protein -
MUU77_RS17565 (MUU77_17565) 3773772..3773978 - 207 WP_245089669.1 hypothetical protein -
MUU77_RS17570 (MUU77_17570) 3774077..3774280 - 204 Protein_3460 DUF3817 domain-containing protein -
MUU77_RS17575 (MUU77_17575) 3774342..3774773 - 432 WP_245089672.1 hypothetical protein -
MUU77_RS17580 (MUU77_17580) 3774966..3775211 + 246 WP_245089675.1 helix-turn-helix transcriptional regulator -
MUU77_RS17585 (MUU77_17585) 3775393..3776487 - 1095 WP_245089678.1 crosslink repair DNA glycosylase YcaQ family protein -
MUU77_RS17590 (MUU77_17590) 3776527..3776739 - 213 WP_245089681.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MUU77_RS17595 (MUU77_17595) 3776745..3776939 - 195 WP_245089684.1 type II toxin-antitoxin system HicA family toxin Toxin
MUU77_RS17600 (MUU77_17600) 3777032..3779725 - 2694 WP_245089687.1 pyruvate dehydrogenase (acetyl-transferring), homodimeric type -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 6849.91 Da        Isoelectric Point: 11.3688

>T241700 WP_245089684.1 NZ_CP095187:c3776939-3776745 [Pseudoxanthomonas sp. F37]
VPPKIRDVLQQLKDAGWQQVGQTGSHRQFKHPTLPGRVTVAGKPGDDVAPGTLASILKQAGIKR

Download         Length: 195 bp

>T241700 NZ_OD940434:1768694-1769038 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAACAAACGCGCATGTTTCGA
CCCTACTTACGGTATCATATTTGTAAATCAAAATTTAACACCAACAGAACAAGAAGAAGCAATATATCACGAATTAAAGC
ATGTAGAAGACCATGTGGATATAATGGCATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAATCCGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAATTTATTTGAAATAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7280.29 Da        Isoelectric Point: 4.1511

>AT241700 WP_245089681.1 NZ_CP095187:c3776739-3776527 [Pseudoxanthomonas sp. F37]
MRYAIVIEQAGGNYSAYVPDLPGCVATGATKAEVEVLIHDAIALHLAGLREDGVAIPVPSSQVEYIDVAA

Download         Length: 213 bp

>AT241700 NZ_OD940434:1768340-1768675 [Enterococcus faecalis]
ATGACAGTGTTTGATAGGATCAAATTATTAGCAAAAGAGAGAGGAAAATCCTTAAATCGAATCGAAGAAGAATTAGGTTT
ACCAAAAAATGTTCTGTATCGTATGAAAACTTCCGATAATCCTACTAAAGATAGACTAGAAACTTTAGCTAATTACTTTG
ATGTATCTGTAGATTATCTATTGGGAAGAACTGATAATACTAAAGCAACTGATGAAAAAAAATCTGATGATTTAGATGAT
GTACTGGATAACGTCATGAGCTTTGACGGTAAACCGCTTGATGATCATGACAGAGAAGTTATCCGTGCATATTTAAAGGG
TAGATTCGGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References