Detailed information of TA system TA241697

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 2188595..2189007
• Replicon: chromosome
• Accession: NZ_CP095186
• Organism: Pseudoxanthomonas mexicana strain F31

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MUU75_RS10345
• Protein ID: WP_245089684.1
• Coordinates: 2188813..2189007 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MUU75_RS10340
• Protein ID: WP_245089681.1
• Coordinates: 2188595..2188807 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUU75_RS10315 (MUU75_10315)	2185750..2186142	-	393	Protein_2025	pyruvate dehydrogenase (acetyl-transferring), homodimeric type	-
MUU75_RS10320 (MUU75_10320)	2186145..2186348	-	204	Protein_2026	DUF3817 domain-containing protein	-
MUU75_RS10325 (MUU75_10325)	2186410..2186841	-	432	WP_245089672.1	hypothetical protein	-
MUU75_RS10330 (MUU75_10330)	2187034..2187279	+	246	WP_245089675.1	helix-turn-helix transcriptional regulator	-
MUU75_RS10335 (MUU75_10335)	2187461..2188555	-	1095	WP_245089678.1	crosslink repair DNA glycosylase YcaQ family protein	-
MUU75_RS10340 (MUU75_10340)	2188595..2188807	-	213	WP_245089681.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MUU75_RS10345 (MUU75_10345)	2188813..2189007	-	195	WP_245089684.1	type II toxin-antitoxin system HicA family toxin	Toxin
MUU75_RS10350 (MUU75_10350)	2189100..2191793	-	2694	WP_245089687.1	pyruvate dehydrogenase (acetyl-transferring), homodimeric type	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2184639..2196202	11563

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 6849.91 Da
• Isoelectric Point: 11.3688

>T241697 WP_245089684.1 NZ_CP095186:c2189007-2188813 [Pseudoxanthomonas mexicana]
VPPKIRDVLQQLKDAGWQQVGQTGSHRQFKHPTLPGRVTVAGKPGDDVAPGTLASILKQAGIKR

Nucleotide

• Length: 195 bp

>T241697 NZ_OD940434:c127373-126735 [Enterococcus faecalis]
ATGATACTAAATAAGAAAAAATTATATTTCGAAACACAGGCATTTACTGACAAACTTATAAATGAAATTTCAATCAATAT
GTCTAAAAGAAAAGAACTCATCAATTGTTATGATATTGAAGCCTACGTAAAAGAAACCGAAAACATTGATTTTTTTGATT
ATCCATTCAAAAAACAATCTAAAAAATTAATCTGGGGATCAGTAACAAAAATTGGTGATGTAACTATGGTAGCGACTGCC
CAACACTTGAAAATAGAAATTAAAAATTTTACGAAAATGCACGAAATAATTCATCATTATTTTGACTATACGACAGATAT
GCCTAACAATGAAAAATCATTTGATACACTACTTATAAAAAAGGGCTATCTTCCTGAAGATTATCCTAAAGAATTCAGAG
CAAATAAGGGTGCCGGAATGTTACTTATTAATAAAAAAGCCTTAAAGTATGCATTTAGTACTTATGATGATCTTGAAAAA
ATGGCTAGTTTTTTCAACGTAAACGATATAGTTCTCAAGATAAGAATTCTTGACGAATTAATCTATTCCCACAACTTATC
TTATAAACAAGCCAATCTTATTTATAATAGTTACTATTTTCAACAACAAACACAACTTAAAGAGATTTTACTCAAATAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7280.29 Da
• Isoelectric Point: 4.1511

>AT241697 WP_245089681.1 NZ_CP095186:c2188807-2188595 [Pseudoxanthomonas mexicana]
MRYAIVIEQAGGNYSAYVPDLPGCVATGATKAEVEVLIHDAIALHLAGLREDGVAIPVPSSQVEYIDVAA

Nucleotide

• Length: 213 bp

>AT241697 NZ_OD940434:c127754-127380 [Enterococcus faecalis]
ATGAAAACTTACGAAAAGATAAAACAATTAAGAGAAAATAGAGAAATCACTCAAAAAGAAATTTCAAACGCACTAGACAT
TAATGTTAGTGTATATAATAAAATAGAACTTGGAATACGTCCATTAAGAGAAGAAGAACTTACTGCTATTGCTGATTTTT
TTAATGTTTCAATTGATTATTTAACAGGACGCACTGATAACCCTACAACACCTTCAAATAATCAAAAAGAAGCTGGACAA
AATATTATTTCACATTTCAGATTAAACACTAATGATTTAAGTTCTGATGACATAGAAGAATTAGAAAAAGAATTGATTGA
TTTTCAAGAATTTCTTATAAAACGAGCAAAAGAAAGAAAAAAAAAGAGTGAGTAA