Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3985321..3985978 Replicon chromosome
Accession NZ_CP095180
Organism Enterobacter roggenkampii strain Ek140

Toxin (Protein)


Gene name cptA Uniprot ID W7P4L3
Locus tag MUY32_RS19235 Protein ID WP_023326024.1
Coordinates 3985321..3985731 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag MUY32_RS19240 Protein ID WP_006178375.1
Coordinates 3985712..3985978 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY32_RS19215 (MUY32_19215) 3981314..3983047 - 1734 WP_025912450.1 single-stranded-DNA-specific exonuclease RecJ -
MUY32_RS19220 (MUY32_19220) 3983053..3983766 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MUY32_RS19225 (MUY32_19225) 3983795..3984691 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
MUY32_RS19230 (MUY32_19230) 3984793..3985314 + 522 WP_045909912.1 flavodoxin FldB -
MUY32_RS19235 (MUY32_19235) 3985321..3985731 - 411 WP_023326024.1 protein YgfX Toxin
MUY32_RS19240 (MUY32_19240) 3985712..3985978 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
MUY32_RS19245 (MUY32_19245) 3986273..3987253 + 981 WP_248275221.1 tRNA-modifying protein YgfZ -
MUY32_RS19250 (MUY32_19250) 3987338..3987997 - 660 WP_021242052.1 hemolysin III family protein -
MUY32_RS19255 (MUY32_19255) 3988263..3988994 + 732 WP_008499714.1 MurR/RpiR family transcriptional regulator -
MUY32_RS19260 (MUY32_19260) 3989111..3990544 + 1434 WP_249456583.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16063.06 Da        Isoelectric Point: 10.9468

>T241693 WP_023326024.1 NZ_CP095180:c3985731-3985321 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T241693 NZ_OD940431:2707041-2707184 [Enterococcus faecalis]
ATGAATGTAAGTGCTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
CTCTTTTATCGCAACGTTAATCTTCGGAATCCTAAAAGCTGTTAAAGAAGACAAGAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT241693 WP_006178375.1 NZ_CP095180:c3985978-3985712 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241693 NZ_OD940431:c2707346-2707116 [Enterococcus faecalis]
AGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATAATAGCATTGAAAAGAGAGATATGCTGTAACAT
ACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATTTATAAAAAATAACCGTACTCGCTAAAGTAGAC
GGTTATTTTTTCTTGTCTTCTTTAACAGCTTTTAGGATTCCGAAGATTAACGTTGCGATAAAAGAGCCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W7P4L3

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References