Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 313583..314179 Replicon chromosome
Accession NZ_CP095180
Organism Enterobacter roggenkampii strain Ek140

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag MUY32_RS01455 Protein ID WP_023293553.1
Coordinates 313877..314179 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag MUY32_RS01450 Protein ID WP_021242718.1
Coordinates 313583..313870 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY32_RS01445 (MUY32_01445) 311955..313586 + 1632 WP_008503411.1 Na/Pi cotransporter family protein -
MUY32_RS01450 (MUY32_01450) 313583..313870 - 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
MUY32_RS01455 (MUY32_01455) 313877..314179 - 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUY32_RS01460 (MUY32_01460) 314377..315249 + 873 WP_008503414.1 23S rRNA pseudouridine(2604) synthase RluF -
MUY32_RS01465 (MUY32_01465) 315250..315522 - 273 WP_233396208.1 DUF3811 domain-containing protein -
MUY32_RS01470 (MUY32_01470) 315573..316517 - 945 WP_248275174.1 bile acid:sodium symporter family protein -
MUY32_RS01475 (MUY32_01475) 316623..318197 - 1575 WP_248275173.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T241681 WP_023293553.1 NZ_CP095180:c314179-313877 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T241681 NZ_OD940422:c1100322-1100179 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT241681 WP_021242718.1 NZ_CP095180:c313870-313583 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp

>AT241681 NZ_OD940422:1100423-1100576 [Enterococcus faecalis]
TTTTTAGGGAATTGTGCTATAATAAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References