Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yafW/CbtA-CbeA |
| Location | 77826..78619 | Replicon | chromosome |
| Accession | NZ_CP095180 | ||
| Organism | Enterobacter roggenkampii strain Ek140 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | MUY32_RS00350 | Protein ID | WP_057057874.1 |
| Coordinates | 77826..78203 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EBQ7 |
| Locus tag | MUY32_RS00355 | Protein ID | WP_001548930.1 |
| Coordinates | 78293..78619 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUY32_RS00315 (MUY32_00315) | 73439..73963 | + | 525 | WP_008500115.1 | lipocalin family protein | - |
| MUY32_RS00320 (MUY32_00320) | 74042..75088 | + | 1047 | WP_059362236.1 | class I SAM-dependent methyltransferase | - |
| MUY32_RS00325 (MUY32_00325) | 75155..75610 | + | 456 | WP_123923097.1 | acetyltransferase | - |
| MUY32_RS00330 (MUY32_00330) | 75600..75767 | - | 168 | Protein_65 | hydroxyacid dehydrogenase | - |
| MUY32_RS00335 (MUY32_00335) | 76202..77047 | - | 846 | WP_057057876.1 | DUF4942 domain-containing protein | - |
| MUY32_RS00340 (MUY32_00340) | 77132..77329 | - | 198 | WP_000839269.1 | DUF957 domain-containing protein | - |
| MUY32_RS00345 (MUY32_00345) | 77341..77829 | - | 489 | WP_001547769.1 | DUF5983 family protein | - |
| MUY32_RS00350 (MUY32_00350) | 77826..78203 | - | 378 | WP_057057874.1 | TA system toxin CbtA family protein | Toxin |
| MUY32_RS00355 (MUY32_00355) | 78293..78619 | - | 327 | WP_001548930.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| MUY32_RS00360 (MUY32_00360) | 78638..78859 | - | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| MUY32_RS00365 (MUY32_00365) | 78868..79344 | - | 477 | WP_000811693.1 | RadC family protein | - |
| MUY32_RS00370 (MUY32_00370) | 79360..79818 | - | 459 | WP_057057873.1 | antirestriction protein | - |
| MUY32_RS00375 (MUY32_00375) | 79916..80155 | - | 240 | WP_057057871.1 | DUF905 domain-containing protein | - |
| MUY32_RS00380 (MUY32_00380) | 80232..80699 | - | 468 | WP_001547765.1 | protein YkfB | - |
| MUY32_RS00385 (MUY32_00385) | 80722..81165 | - | 444 | WP_057057870.1 | hypothetical protein | - |
| MUY32_RS00390 (MUY32_00390) | 81165..81401 | - | 237 | WP_001115854.1 | protein YpjK | - |
| MUY32_RS00395 (MUY32_00395) | 81438..82139 | - | 702 | WP_057057867.1 | WYL domain-containing protein | - |
| MUY32_RS00400 (MUY32_00400) | 82357..83178 | - | 822 | WP_249456745.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | wza | 67487..118785 | 51298 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14145.06 Da Isoelectric Point: 7.3524
>T241680 WP_057057874.1 NZ_CP095180:c78203-77826 [Enterobacter roggenkampii]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTHDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTHDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T241680 NZ_CP095180:c78203-77826 [Enterobacter roggenkampii]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCACGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCACGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12301.97 Da Isoelectric Point: 7.0273
>AT241680 WP_001548930.1 NZ_CP095180:c78619-78293 [Enterobacter roggenkampii]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
Download Length: 327 bp
>AT241680 NZ_CP095180:c78619-78293 [Enterobacter roggenkampii]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCTTCGGCTCCTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAA
AAAGTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCTTCGGCTCCTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAA
AAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|