Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 56975..57618 | Replicon | plasmid pK528_mcr-10 |
| Accession | NZ_CP095178 | ||
| Organism | Enterobacter hormaechei strain K528 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A155IU92 |
| Locus tag | MUY31_RS22940 | Protein ID | WP_000754567.1 |
| Coordinates | 56975..57391 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A155IUD1 |
| Locus tag | MUY31_RS22945 | Protein ID | WP_023293777.1 |
| Coordinates | 57388..57618 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUY31_RS22910 (MUY31_22910) | 52161..52742 | + | 582 | WP_032676110.1 | TetR/AcrR family transcriptional regulator | - |
| MUY31_RS22915 (MUY31_22915) | 52747..53085 | + | 339 | WP_000888080.1 | carboxymuconolactone decarboxylase family protein | - |
| MUY31_RS22920 (MUY31_22920) | 53115..53444 | - | 330 | WP_008502229.1 | thioredoxin family protein | - |
| MUY31_RS22925 (MUY31_22925) | 53657..54763 | + | 1107 | WP_006687059.1 | alkene reductase | - |
| MUY31_RS22930 (MUY31_22930) | 54829..55530 | + | 702 | WP_008502228.1 | DsbA family oxidoreductase | - |
| MUY31_RS22935 (MUY31_22935) | 55656..56624 | + | 969 | WP_176311895.1 | IS5-like element IS903B family transposase | - |
| MUY31_RS22940 (MUY31_22940) | 56975..57391 | - | 417 | WP_000754567.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MUY31_RS22945 (MUY31_22945) | 57388..57618 | - | 231 | WP_023293777.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| MUY31_RS22950 (MUY31_22950) | 57756..58310 | + | 555 | WP_161646454.1 | hypothetical protein | - |
| MUY31_RS22955 (MUY31_22955) | 58398..58469 | - | 72 | Protein_67 | hypothetical protein | - |
| MUY31_RS22960 (MUY31_22960) | 58599..59804 | + | 1206 | WP_006797591.1 | AAA family ATPase | - |
| MUY31_RS22965 (MUY31_22965) | 59804..60778 | + | 975 | WP_000064119.1 | ParB family protein | - |
| MUY31_RS22970 (MUY31_22970) | 60860..62131 | - | 1272 | WP_032627083.1 | Y-family DNA polymerase | - |
| MUY31_RS22975 (MUY31_22975) | 62131..62562 | - | 432 | WP_006796638.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | catA1 / ant(3'')-Ia / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaSHV-12 / qnrB1 / dfrA14 / tet(A) / mcr-10 | mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA | 1..148937 | 148937 | |
| - | flank | IS/Tn | - | - | 55656..56624 | 968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15108.61 Da Isoelectric Point: 8.5403
>T241678 WP_000754567.1 NZ_CP095178:c57391-56975 [Enterobacter hormaechei]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVK
Download Length: 417 bp
>T241678 NZ_OD940421:c37286-36945 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8706.73 Da Isoelectric Point: 4.4299
>AT241678 WP_023293777.1 NZ_CP095178:c57618-57388 [Enterobacter hormaechei]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAQREDVVSDEGRFDP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAQREDVVSDEGRFDP
Download Length: 231 bp
>AT241678 NZ_OD940421:c37516-37286 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A155IU92 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A155IUD1 |