Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3804940..3805597 Replicon chromosome
Accession NZ_CP095177
Organism Enterobacter hormaechei strain K528

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag MUY31_RS18330 Protein ID WP_022649305.1
Coordinates 3804940..3805350 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag MUY31_RS18335 Protein ID WP_003863437.1
Coordinates 3805331..3805597 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY31_RS18310 (MUY31_18310) 3800938..3802671 - 1734 WP_048242034.1 single-stranded-DNA-specific exonuclease RecJ -
MUY31_RS18315 (MUY31_18315) 3802677..3803390 - 714 WP_048242037.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MUY31_RS18320 (MUY31_18320) 3803419..3804315 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
MUY31_RS18325 (MUY31_18325) 3804417..3804938 + 522 WP_003863440.1 flavodoxin FldB -
MUY31_RS18330 (MUY31_18330) 3804940..3805350 - 411 WP_022649305.1 protein YgfX Toxin
MUY31_RS18335 (MUY31_18335) 3805331..3805597 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
MUY31_RS18340 (MUY31_18340) 3805892..3806872 + 981 WP_003863435.1 tRNA-modifying protein YgfZ -
MUY31_RS18345 (MUY31_18345) 3806958..3807617 - 660 WP_003863433.1 hemolysin III family protein -
MUY31_RS18350 (MUY31_18350) 3807884..3808615 + 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
MUY31_RS18355 (MUY31_18355) 3808732..3810165 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T241677 WP_022649305.1 NZ_CP095177:c3805350-3804940 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T241677 NZ_OD940420:2873147-2873290 [Enterococcus faecalis]
ATGAATGTAAGTGCTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT241677 WP_003863437.1 NZ_CP095177:c3805597-3805331 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT241677 NZ_OD940420:c2873481-2873223 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAA
TGATAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTATTT
AAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAA
GCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References