Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2311640..2312379 Replicon chromosome
Accession NZ_CP095177
Organism Enterobacter hormaechei strain K528

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag MUY31_RS11150 Protein ID WP_032609220.1
Coordinates 2311640..2312125 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag MUY31_RS11155 Protein ID WP_003857131.1
Coordinates 2312113..2312379 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY31_RS11120 (MUY31_11120) 2307131..2307703 + 573 WP_045346197.1 NAD(P)H-dependent oxidoreductase -
MUY31_RS11125 (MUY31_11125) 2307706..2308725 + 1020 WP_199130010.1 aldo/keto reductase -
MUY31_RS11130 (MUY31_11130) 2308764..2309141 + 378 WP_023292403.1 DUF1330 domain-containing protein -
MUY31_RS11135 (MUY31_11135) 2309235..2309783 + 549 WP_045346251.1 NAD(P)H-dependent oxidoreductase -
MUY31_RS11140 (MUY31_11140) 2309824..2310519 + 696 WP_045346199.1 antibiotic biosynthesis monooxygenase -
MUY31_RS11145 (MUY31_11145) 2310535..2311338 + 804 WP_048240777.1 carboxymuconolactone decarboxylase family protein -
MUY31_RS11150 (MUY31_11150) 2311640..2312125 - 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
MUY31_RS11155 (MUY31_11155) 2312113..2312379 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
MUY31_RS11160 (MUY31_11160) 2312443..2313372 - 930 Protein_2178 LysR family transcriptional regulator -
MUY31_RS11165 (MUY31_11165) 2313502..2314890 + 1389 WP_048240775.1 MFS transporter -
MUY31_RS11170 (MUY31_11170) 2314912..2315907 - 996 WP_048240773.1 DUF2891 domain-containing protein -
MUY31_RS11175 (MUY31_11175) 2315917..2316903 - 987 WP_022651202.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T241665 WP_032609220.1 NZ_CP095177:c2312125-2311640 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T241665 NZ_NQJO01000001:2794498-2794716 [Erwinia amylovora]
ATGACTGACAAACTTCTAACGAAAACTGACTACCTGATGCGCCTCAGGCGTTGTCGTTCAATCGATACACTTGAACGCGT
GATTGAAAAGAACAAGTACGAATTATCTGATGATGAACTGGCTGTATTTTATTCAGCCGCCGATCACCGTCTTGCTGAAC
TAACCATGAATAAGCTGTACGACAAAGTACCGGTCGCTGTCTGGAAGTTTGTCCGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT241665 WP_003857131.1 NZ_CP095177:c2312379-2312113 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT241665 NZ_NQJO01000001:2794089-2794478 [Erwinia amylovora]
ATGGACGAATACTCACCGAAAAGGCATGATATTGCGCAGCTGAAATTCTTATGTGAAAACCTGTATGATGAAAGTCTGGC
TACGTTAGGCGACAGCCATCATGGCTGGGTTAACGACCCCACCTCAACGAGCAATCTTCAGCTTAACGACCTGATAGAGC
ACATTGCAGCATTCACAATGAATTACAAAATCAAGCATATCGAAGACAGCGATCTGATAAGTCAAATTGATGAGTATCTG
GACGACACCTTTATGCTTTTCAGCAATTACGGTGTCAACAATCTTGACTTACAACGCTGGCAAAAATCAGCGAAGCGATT
GTTTAACATTTTTGCTAAAGAATGCGTAATGAGCCAGATCCAGTCCAGCCATTCATTTAGCAGCCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References