Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 291956..292552 Replicon chromosome
Accession NZ_CP095177
Organism Enterobacter hormaechei strain K528

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag MUY31_RS01420 Protein ID WP_023315213.1
Coordinates 292250..292552 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag MUY31_RS01415 Protein ID WP_022650216.1
Coordinates 291956..292243 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY31_RS01410 (MUY31_01410) 290328..291959 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
MUY31_RS01415 (MUY31_01415) 291956..292243 - 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
MUY31_RS01420 (MUY31_01420) 292250..292552 - 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUY31_RS01425 (MUY31_01425) 292750..293622 + 873 WP_045346556.1 23S rRNA pseudouridine(2604) synthase RluF -
MUY31_RS01430 (MUY31_01430) 293623..293895 - 273 WP_003860346.1 DUF3811 domain-containing protein -
MUY31_RS01435 (MUY31_01435) 293946..294890 - 945 WP_022650218.1 ketopantoate/pantoate/pantothenate transporter PanS -
MUY31_RS01440 (MUY31_01440) 294984..296333 - 1350 WP_045895713.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T241663 WP_023315213.1 NZ_CP095177:c292552-292250 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T241663 NZ_NQJO01000001:c1980245-1980066 [Erwinia amylovora]
ATGGATAGCAGGAATGCAATAGCAATGATAGAGGCCGATGGATGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATCCCCAAAAGGACATACCGCTACCAACGCTGAAAAGCATTA
AAAAACAGGCGGGGCTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT241663 WP_022650216.1 NZ_CP095177:c292243-291956 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT241663 NZ_NQJO01000001:c1980043-1979633 [Erwinia amylovora]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCCGATATTCCAGGCTGCTTCTCTGG
CGGCGACAATTATCAGGATGCGATTGAGAGCGCGCGTGAGGCTATCGACGCGCATATCGAATTACTGGTGGAAGATGGCG
AAGCGGTGCCGGAAGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTTGGTGTGGTGTGGGCGCTGGTAGAT
GTGGACGTTACCCGGCTGATGGGGAAAGCGGAAAAAATCAATGTTACGCTCCCTTCTTTACTGATCCGCCGTATCGATCA
GTTTGTCGCTGCACATCCTGAGTACGGTAGCCGTTCCGGCTTCCTGTCCCGCGTGGCGGCTGATAAAGTGATTGGTCGCG
AAAAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References