Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 13947..14472 | Replicon | plasmid pK666_mcr-10 |
| Accession | NZ_CP095171 | ||
| Organism | Enterobacter roggenkampii strain K666 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | W8UQV6 |
| Locus tag | MUY33_RS23920 | Protein ID | WP_001568026.1 |
| Coordinates | 13947..14252 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | W8V2V6 |
| Locus tag | MUY33_RS23925 | Protein ID | WP_001568025.1 |
| Coordinates | 14254..14472 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUY33_RS23900 (MUY33_23900) | 10417..11685 | + | 1269 | WP_019705993.1 | ISL3-like element ISKpn25 family transposase | - |
| MUY33_RS23905 (MUY33_23905) | 12020..13036 | - | 1017 | WP_020315256.1 | hypothetical protein | - |
| MUY33_RS23910 (MUY33_23910) | 13033..13356 | - | 324 | WP_022644730.1 | hypothetical protein | - |
| MUY33_RS23915 (MUY33_23915) | 13383..13778 | - | 396 | WP_072158608.1 | hypothetical protein | - |
| MUY33_RS23920 (MUY33_23920) | 13947..14252 | - | 306 | WP_001568026.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| MUY33_RS23925 (MUY33_23925) | 14254..14472 | - | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| MUY33_RS23930 (MUY33_23930) | 15100..15330 | + | 231 | WP_021312767.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| MUY33_RS23935 (MUY33_23935) | 15327..15743 | + | 417 | WP_021312768.1 | type II toxin-antitoxin system VapC family toxin | - |
| MUY33_RS23940 (MUY33_23940) | 15841..16011 | - | 171 | WP_228264702.1 | helix-turn-helix domain-containing protein | - |
| MUY33_RS23945 (MUY33_23945) | 16051..16753 | - | 703 | Protein_16 | IS6-like element IS26 family transposase | - |
| MUY33_RS23950 (MUY33_23950) | 17058..18059 | - | 1002 | Protein_17 | IS110-like element IS4321 family transposase | - |
| MUY33_RS23955 (MUY33_23955) | 18183..18885 | + | 703 | Protein_18 | IS6-like element IS26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1B / blaLAP-2 / qnrS1 / mcr-10 | mrkF / mrkD / mrkC / mrkB / mrkA | 1..136140 | 136140 | |
| - | inside | IScluster/Tn | blaTEM-1B / blaLAP-2 / qnrS1 | - | 10417..28276 | 17859 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11645.32 Da Isoelectric Point: 5.6919
>T241659 WP_001568026.1 NZ_CP095171:c14252-13947 [Enterobacter roggenkampii]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T241659 NZ_LT996891:c2610614-2610153 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8392.34 Da Isoelectric Point: 4.7405
>AT241659 WP_001568025.1 NZ_CP095171:c14472-14254 [Enterobacter roggenkampii]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT241659 NZ_LT996891:c2610941-2610627 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A514EZN1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4ZZP8 |