Detailed information of TA system TA241658

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4043035..4043692
• Replicon: chromosome
• Accession: NZ_CP095170
• Organism: Enterobacter roggenkampii strain K666

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MUY33_RS19600
• Protein ID: WP_032653292.1
• Coordinates: 4043035..4043445 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W7NX65
• Locus tag: MUY33_RS19605
• Protein ID: WP_006178375.1
• Coordinates: 4043426..4043692 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUY33_RS19580 (MUY33_19580)	4039028..4040761	-	1734	WP_032653290.1	single-stranded-DNA-specific exonuclease RecJ	-
MUY33_RS19585 (MUY33_19585)	4040767..4041480	-	714	WP_008499708.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MUY33_RS19590 (MUY33_19590)	4041509..4042405	-	897	WP_008499709.1	site-specific tyrosine recombinase XerD	-
MUY33_RS19595 (MUY33_19595)	4042507..4043028	+	522	WP_023309099.1	flavodoxin FldB	-
MUY33_RS19600 (MUY33_19600)	4043035..4043445	-	411	WP_032653292.1	protein YgfX	Toxin
MUY33_RS19605 (MUY33_19605)	4043426..4043692	-	267	WP_006178375.1	FAD assembly factor SdhE	Antitoxin
MUY33_RS19610 (MUY33_19610)	4043987..4044967	+	981	WP_032653295.1	tRNA-modifying protein YgfZ	-
MUY33_RS19615 (MUY33_19615)	4045052..4045711	-	660	WP_032653297.1	hemolysin III family protein	-
MUY33_RS19620 (MUY33_19620)	4045977..4046708	+	732	WP_021242053.1	MurR/RpiR family transcriptional regulator	-
MUY33_RS19625 (MUY33_19625)	4046825..4048258	+	1434	WP_023294510.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16069.03 Da
• Isoelectric Point: 10.9468

>T241658 WP_032653292.1 NZ_CP095170:c4043445-4043035 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKADGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Nucleotide

• Length: 411 bp

>T241658 NZ_LT996891:2231581-2231733 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10569.05 Da
• Isoelectric Point: 5.1340

>AT241658 WP_006178375.1 NZ_CP095170:c4043692-4043426 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT241658 NZ_LT996891:2230957-2231556 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: W7NX65