Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3781195..3781862 Replicon chromosome
Accession NZ_CP095170
Organism Enterobacter roggenkampii strain K666

Toxin (Protein)


Gene name ypjF Uniprot ID A0A2I8SC83
Locus tag MUY33_RS18335 Protein ID WP_054626383.1
Coordinates 3781533..3781862 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A2I8SA04
Locus tag MUY33_RS18330 Protein ID WP_054626382.1
Coordinates 3781195..3781512 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY33_RS18290 (MUY33_18290) 3776643..3777470 + 828 WP_249488741.1 DUF932 domain-containing protein -
MUY33_RS18295 (MUY33_18295) 3777697..3778392 + 696 WP_054626378.1 hypothetical protein -
MUY33_RS18300 (MUY33_18300) 3778430..3778597 + 168 Protein_3587 DUF4339 domain-containing protein -
MUY33_RS18305 (MUY33_18305) 3778666..3779574 + 909 WP_249488742.1 Ivy family c-type lysozyme inhibitor -
MUY33_RS18310 (MUY33_18310) 3779674..3779913 + 240 WP_054626379.1 DUF905 domain-containing protein -
MUY33_RS18315 (MUY33_18315) 3779997..3780455 + 459 WP_249488743.1 antirestriction protein -
MUY33_RS18320 (MUY33_18320) 3780471..3780947 + 477 WP_054626380.1 RadC family protein -
MUY33_RS18325 (MUY33_18325) 3780956..3781177 + 222 WP_054626381.1 DUF987 domain-containing protein -
MUY33_RS18330 (MUY33_18330) 3781195..3781512 + 318 WP_054626382.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MUY33_RS18335 (MUY33_18335) 3781533..3781862 + 330 WP_054626383.1 TA system toxin CbtA family protein Toxin
MUY33_RS18340 (MUY33_18340) 3782210..3783256 - 1047 WP_032653095.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
MUY33_RS18345 (MUY33_18345) 3783240..3784016 - 777 WP_032653097.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
MUY33_RS18350 (MUY33_18350) 3784150..3784941 - 792 WP_249488744.1 nucleotidyltransferase domain-containing protein -
MUY33_RS18355 (MUY33_18355) 3785247..3785561 - 315 WP_047721676.1 hypothetical protein -
MUY33_RS18360 (MUY33_18360) 3785964..3786320 + 357 WP_008502540.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3735976..3785561 49585


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12324.29 Da        Isoelectric Point: 7.1642

>T241657 WP_054626383.1 NZ_CP095170:3781533-3781862 [Enterobacter roggenkampii]
MKTLPATTPQAAKLCLPPVAVWQMLLTRLLETHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDRNGF
SWQEQTPYISVVDILRARRSTGLLKNNVK

Download         Length: 330 bp

>T241657 NZ_LT996891:2074248-2074610 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11741.53 Da        Isoelectric Point: 7.0161

>AT241657 WP_054626382.1 NZ_CP095170:3781195-3781512 [Enterobacter roggenkampii]
MSKITWGLQRNITPHLGARLVQEGNRLHYLADRASITGKISDAECLKLDVAFPHFISQMELMLTTGEMNPCHAHCVILYH
NGFTCEADTLGSCGYVYVAVYPTQR

Download         Length: 318 bp

>AT241657 NZ_LT996891:2074081-2074251 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8SC83

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8SA04

References