Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 3781195..3781862 | Replicon | chromosome |
| Accession | NZ_CP095170 | ||
| Organism | Enterobacter roggenkampii strain K666 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A2I8SC83 |
| Locus tag | MUY33_RS18335 | Protein ID | WP_054626383.1 |
| Coordinates | 3781533..3781862 (+) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A2I8SA04 |
| Locus tag | MUY33_RS18330 | Protein ID | WP_054626382.1 |
| Coordinates | 3781195..3781512 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUY33_RS18290 (MUY33_18290) | 3776643..3777470 | + | 828 | WP_249488741.1 | DUF932 domain-containing protein | - |
| MUY33_RS18295 (MUY33_18295) | 3777697..3778392 | + | 696 | WP_054626378.1 | hypothetical protein | - |
| MUY33_RS18300 (MUY33_18300) | 3778430..3778597 | + | 168 | Protein_3587 | DUF4339 domain-containing protein | - |
| MUY33_RS18305 (MUY33_18305) | 3778666..3779574 | + | 909 | WP_249488742.1 | Ivy family c-type lysozyme inhibitor | - |
| MUY33_RS18310 (MUY33_18310) | 3779674..3779913 | + | 240 | WP_054626379.1 | DUF905 domain-containing protein | - |
| MUY33_RS18315 (MUY33_18315) | 3779997..3780455 | + | 459 | WP_249488743.1 | antirestriction protein | - |
| MUY33_RS18320 (MUY33_18320) | 3780471..3780947 | + | 477 | WP_054626380.1 | RadC family protein | - |
| MUY33_RS18325 (MUY33_18325) | 3780956..3781177 | + | 222 | WP_054626381.1 | DUF987 domain-containing protein | - |
| MUY33_RS18330 (MUY33_18330) | 3781195..3781512 | + | 318 | WP_054626382.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MUY33_RS18335 (MUY33_18335) | 3781533..3781862 | + | 330 | WP_054626383.1 | TA system toxin CbtA family protein | Toxin |
| MUY33_RS18340 (MUY33_18340) | 3782210..3783256 | - | 1047 | WP_032653095.1 | methylated-DNA--[protein]-cysteine S-methyltransferase | - |
| MUY33_RS18345 (MUY33_18345) | 3783240..3784016 | - | 777 | WP_032653097.1 | isocitrate lyase/phosphoenolpyruvate mutase family protein | - |
| MUY33_RS18350 (MUY33_18350) | 3784150..3784941 | - | 792 | WP_249488744.1 | nucleotidyltransferase domain-containing protein | - |
| MUY33_RS18355 (MUY33_18355) | 3785247..3785561 | - | 315 | WP_047721676.1 | hypothetical protein | - |
| MUY33_RS18360 (MUY33_18360) | 3785964..3786320 | + | 357 | WP_008502540.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3735976..3785561 | 49585 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12324.29 Da Isoelectric Point: 7.1642
>T241657 WP_054626383.1 NZ_CP095170:3781533-3781862 [Enterobacter roggenkampii]
MKTLPATTPQAAKLCLPPVAVWQMLLTRLLETHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDRNGF
SWQEQTPYISVVDILRARRSTGLLKNNVK
MKTLPATTPQAAKLCLPPVAVWQMLLTRLLETHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDRNGF
SWQEQTPYISVVDILRARRSTGLLKNNVK
Download Length: 330 bp
>T241657 NZ_LT996891:2074248-2074610 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
Antitoxin
Download Length: 106 a.a. Molecular weight: 11741.53 Da Isoelectric Point: 7.0161
>AT241657 WP_054626382.1 NZ_CP095170:3781195-3781512 [Enterobacter roggenkampii]
MSKITWGLQRNITPHLGARLVQEGNRLHYLADRASITGKISDAECLKLDVAFPHFISQMELMLTTGEMNPCHAHCVILYH
NGFTCEADTLGSCGYVYVAVYPTQR
MSKITWGLQRNITPHLGARLVQEGNRLHYLADRASITGKISDAECLKLDVAFPHFISQMELMLTTGEMNPCHAHCVILYH
NGFTCEADTLGSCGYVYVAVYPTQR
Download Length: 318 bp
>AT241657 NZ_LT996891:2074081-2074251 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I8SC83 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I8SA04 |