Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1727919..1728716 Replicon chromosome
Accession NZ_CP095170
Organism Enterobacter roggenkampii strain K666

Toxin (Protein)


Gene name KacT Uniprot ID A0A155TD66
Locus tag MUY33_RS08280 Protein ID WP_032651255.1
Coordinates 1728195..1728716 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag MUY33_RS08275 Protein ID WP_008499829.1
Coordinates 1727919..1728188 (+) Length 90 a.a.

Genomic Context

MUY33_RS08250MUY33_RS08265MUY33_RS08270MUY33_RS08275MUY33_RS08280MUY33_RS08245MUY33_RS08255MUY33_RS08260MUY33_RS08285MUY33_RS08290MUY33_RS08295MUY33_RS08300MUY33_RS08305MUY33_RS08310
Location: 1724138..1725379 (1242 bp)
Type: Others
Protein ID: WP_032651252.1
Location: 1726651..1726821 (171 bp)
Type: Others
Protein ID: WP_013097201.1
Location: 1726940..1727857 (918 bp)
Type: Others
Protein ID: WP_025912980.1
Location: 1727919..1728188 (270 bp)
Type: Antitoxin
Protein ID: WP_008499829.1
Location: 1728195..1728716 (522 bp)
Type: Toxin
Protein ID: WP_032651255.1
Location: 1723542..1723985 (444 bp)
Type: Others
Protein ID: WP_008499834.1
Location: 1725415..1725642 (228 bp)
Type: Others
Protein ID: WP_008499832.1
Location: 1725663..1726259 (597 bp)
Type: Others
Protein ID: WP_008499831.1
Location: 1728790..1730112 (1323 bp)
Type: Others
Protein ID: WP_008499826.1
Location: 1730134..1730628 (495 bp)
Type: Others
Protein ID: WP_008499825.1
Location: 1730638..1731228 (591 bp)
Type: Others
Protein ID: WP_032651257.1
Location: 1731238..1732038 (801 bp)
Type: Others
Protein ID: WP_021240807.1
Location: 1732046..1732432 (387 bp)
Type: Others
Protein ID: WP_008499822.1
Location: 1732444..1733132 (689 bp)
Type: Others
Protein ID: Protein_1616
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MUY33_RS08245 (MUY33_08245)1723542..1723985-444WP_008499834.1helix-turn-helix domain-containing protein-
MUY33_RS08250 (MUY33_08250)1724138..1725379+1242WP_032651252.1bifunctional glucose-1-phosphatase/inositol phosphatase-
MUY33_RS08255 (MUY33_08255)1725415..1725642-228WP_008499832.1YccJ family protein-
MUY33_RS08260 (MUY33_08260)1725663..1726259-597WP_008499831.1NAD(P)H:quinone oxidoreductase-
MUY33_RS08265 (MUY33_08265)1726651..1726821+171WP_013097201.1general stress protein-
MUY33_RS08270 (MUY33_08270)1726940..1727857+918WP_025912980.1DMT family transporter-
MUY33_RS08275 (MUY33_08275)1727919..1728188+270WP_008499829.1DUF1778 domain-containing proteinAntitoxin
MUY33_RS08280 (MUY33_08280)1728195..1728716+522WP_032651255.1GNAT family N-acetyltransferaseToxin
MUY33_RS08285 (MUY33_08285)1728790..1730112-1323WP_008499826.1pyrimidine utilization transport protein G-
MUY33_RS08290 (MUY33_08290)1730134..1730628-495WP_008499825.1pyrimidine utilization flavin reductase protein F-
MUY33_RS08295 (MUY33_08295)1730638..1731228-591WP_032651257.1malonic semialdehyde reductase-
MUY33_RS08300 (MUY33_08300)1731238..1732038-801WP_021240807.1pyrimidine utilization protein D-
MUY33_RS08305 (MUY33_08305)1732046..1732432-387WP_008499822.1pyrimidine utilization protein C-
MUY33_RS08310 (MUY33_08310)1732444..1733132-689Protein_1616pyrimidine utilization protein B-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19714.46 Da        Isoelectric Point: 7.0497

>T241648 WP_032651255.1 NZ_CP095170:1728195-1728716 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

>T241648 NZ_LT996890:2074246-2074608 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT241648 WP_008499829.1 NZ_CP095170:1727919-1728188 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT241648 NZ_LT996890:2074079-2074249 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A155TD66

Antitoxin

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Source
ID
Structure
AlphaFold DBW7PG43

References