241647

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1138223..1138843 Replicon chromosome
Accession NZ_CP095170
Organism Enterobacter roggenkampii strain K666

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag MUY33_RS05480 Protein ID WP_008499287.1
Coordinates 1138223..1138441 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag MUY33_RS05485 Protein ID WP_008499288.1
Coordinates 1138469..1138843 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY33_RS05450 (MUY33_05450) 1134236..1134496 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
MUY33_RS05455 (MUY33_05455) 1134499..1134639 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
MUY33_RS05460 (MUY33_05460) 1134636..1135346 - 711 WP_032656573.1 GNAT family protein -
MUY33_RS05465 (MUY33_05465) 1135448..1136908 + 1461 WP_249488884.1 PLP-dependent aminotransferase family protein -
MUY33_RS05470 (MUY33_05470) 1136880..1137347 - 468 WP_008499285.1 YlaC family protein -
MUY33_RS05475 (MUY33_05475) 1137465..1138016 - 552 WP_008499286.1 maltose O-acetyltransferase -
MUY33_RS05480 (MUY33_05480) 1138223..1138441 - 219 WP_008499287.1 HHA domain-containing protein Toxin
MUY33_RS05485 (MUY33_05485) 1138469..1138843 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
MUY33_RS05490 (MUY33_05490) 1139352..1142498 - 3147 WP_032656576.1 multidrug efflux RND transporter permease subunit AcrB -
MUY33_RS05495 (MUY33_05495) 1142521..1143714 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T241647 WP_008499287.1 NZ_CP095170:c1138441-1138223 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T241647 NZ_LT996890:2054641-2054850 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT241647 WP_008499288.1 NZ_CP095170:c1138843-1138469 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT241647 NZ_LT996890:2054336-2054629 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References