241646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 145577..146184 Replicon chromosome
Accession NZ_CP095170
Organism Enterobacter roggenkampii strain K666

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H0N5B9
Locus tag MUY33_RS00665 Protein ID WP_071993467.1
Coordinates 145577..145762 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A155E9Y3
Locus tag MUY33_RS00670 Protein ID WP_032675741.1
Coordinates 145777..146184 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY33_RS00650 (MUY33_00650) 142009..143547 + 1539 WP_032654516.1 aldehyde dehydrogenase AldB -
MUY33_RS00655 (MUY33_00655) 143544..144509 - 966 WP_063435980.1 LysR family transcriptional regulator -
MUY33_RS00660 (MUY33_00660) 144627..145367 + 741 WP_021242443.1 MipA/OmpV family protein -
MUY33_RS00665 (MUY33_00665) 145577..145762 + 186 WP_071993467.1 type II toxin-antitoxin system HicA family toxin Toxin
MUY33_RS00670 (MUY33_00670) 145777..146184 + 408 WP_032675741.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MUY33_RS00675 (MUY33_00675) 146188..147264 - 1077 WP_032654523.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
MUY33_RS00680 (MUY33_00680) 147610..148305 - 696 WP_032654528.1 L-ribulose-5-phosphate 4-epimerase -
MUY33_RS00685 (MUY33_00685) 148299..149159 - 861 WP_021242445.1 L-ribulose-5-phosphate 3-epimerase -
MUY33_RS00690 (MUY33_00690) 149162..149815 - 654 WP_032654530.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6882.06 Da        Isoelectric Point: 11.2341

>T241646 WP_071993467.1 NZ_CP095170:145577-145762 [Enterobacter roggenkampii]
VKSADVITVLISHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T241646 NZ_LT996890:1995185-1995289 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15010.78 Da        Isoelectric Point: 4.3897

>AT241646 WP_032675741.1 NZ_CP095170:145777-146184 [Enterobacter roggenkampii]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDNALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPG

Download         Length: 408 bp

>AT241646 NZ_LT996890:c1995447-1995284 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0N5B9

Antitoxin

Source ID Structure
AlphaFold DB A0A155E9Y3

References