Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3861494..3862151 Replicon chromosome
Accession NZ_CP095165
Organism Enterobacter roggenkampii strain K475-2

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag MUY30_RS18385 Protein ID WP_021242050.1
Coordinates 3861494..3861904 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag MUY30_RS18390 Protein ID WP_006178375.1
Coordinates 3861885..3862151 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY30_RS18365 (MUY30_18365) 3857487..3859220 - 1734 WP_126288443.1 single-stranded-DNA-specific exonuclease RecJ -
MUY30_RS18370 (MUY30_18370) 3859226..3859939 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MUY30_RS18375 (MUY30_18375) 3859968..3860864 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
MUY30_RS18380 (MUY30_18380) 3860966..3861487 + 522 WP_008499710.1 flavodoxin FldB -
MUY30_RS18385 (MUY30_18385) 3861494..3861904 - 411 WP_021242050.1 protein YgfX Toxin
MUY30_RS18390 (MUY30_18390) 3861885..3862151 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
MUY30_RS18395 (MUY30_18395) 3862446..3863426 + 981 WP_126288441.1 tRNA-modifying protein YgfZ -
MUY30_RS18400 (MUY30_18400) 3863511..3864170 - 660 WP_021242052.1 hemolysin III family protein -
MUY30_RS18405 (MUY30_18405) 3864436..3865167 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
MUY30_RS18410 (MUY30_18410) 3865284..3866717 + 1434 WP_023294510.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T241641 WP_021242050.1 NZ_CP095165:c3861904-3861494 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T241641 NZ_LT996889:c2610611-2610150 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT241641 WP_006178375.1 NZ_CP095165:c3862151-3861885 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241641 NZ_LT996889:c2610938-2610624 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References