Detailed information of TA system TA241630

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 608657..609380
• Replicon: chromosome
• Accession: NZ_CP095165
• Organism: Enterobacter roggenkampii strain K475-2

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MUY30_RS02840
• Protein ID: WP_249469731.1
• Coordinates: 609060..609380 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: MUY30_RS02835
• Protein ID: WP_105607669.1
• Coordinates: 608657..608992 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUY30_RS02795 (MUY30_02795)	604342..605163	+	822	WP_222563667.1	DUF932 domain-containing protein	-
MUY30_RS02800 (MUY30_02800)	605380..606081	+	702	WP_032654806.1	WYL domain-containing protein	-
MUY30_RS02805 (MUY30_02805)	606118..606354	+	237	WP_001115854.1	protein YpjK	-
MUY30_RS02810 (MUY30_02810)	606354..606797	+	444	WP_222563668.1	hypothetical protein	-
MUY30_RS02815 (MUY30_02815)	606820..607287	+	468	WP_249469728.1	protein YkfB	-
MUY30_RS02820 (MUY30_02820)	607364..607603	+	240	WP_053266273.1	DUF905 domain-containing protein	-
MUY30_RS02825 (MUY30_02825)	607703..608152	+	450	WP_166500063.1	antirestriction protein	-
MUY30_RS02830 (MUY30_02830)	608164..608643	+	480	WP_102217336.1	DNA repair protein RadC	-
MUY30_RS02835 (MUY30_02835)	608657..608992	+	336	WP_105607669.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MUY30_RS02840 (MUY30_02840)	609060..609380	+	321	WP_249469731.1	TA system toxin CbtA family protein	Toxin
MUY30_RS02845 (MUY30_02845)	609975..610241	-	267	WP_063149787.1	MazG-like family protein	-
MUY30_RS02850 (MUY30_02850)	610708..611790	+	1083	WP_061716048.1	ImmA/IrrE family metallo-endopeptidase	-
MUY30_RS02855 (MUY30_02855)	611793..612737	-	945	WP_126287558.1	hypothetical protein	-
MUY30_RS02860 (MUY30_02860)	612734..613714	-	981	WP_126287559.1	thymidylate synthase	-
MUY30_RS02865 (MUY30_02865)	613800..614365	-	566	Protein_553	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	fosA	-	601045..620999	19954
	-	flank	IS/Tn	-	-	614198..614365	167

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12110.84 Da
• Isoelectric Point: 6.4799

>T241630 WP_249469731.1 NZ_CP095165:609060-609380 [Enterobacter roggenkampii]
MQISTVPATMPVSSRLSPVQIWQQLLTYLLEHHYGLTLNDTPFHDDAAIKEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQEQTPFVTATDILRARRATGLMNK

Nucleotide

• Length: 321 bp

>T241630 NZ_LT996886:c661817-661392 [Tessaracoccus timonensis]
GTGATCGTCCTCGACACCAACGTCGTCTCGGAGATCTTTCGGTCCTCGCTGGAGCCTCGTGTTGTCGAGTGGCTTGTGTC
GCTGACGGGTGACGTTGCGATCACGTCTGTCACTCTTGCGGAGTTGCTTGCCGGCGTTCGAAGGCTCCCGGAGGGTCGAC
GCAAGGACGCGCTGGCGCGCGGGATTGAGGGAGCGGTAGTGCCGTATCGGGGGAGCCGGTCGGTGCTCGCGTTCGATGCT
GACGCGGCGGAGCGATATGCGGAGGTGCTCGTGTCGCGTGAGGCGGCAGGTGTGCCGGTCAGTACCGTCGACGCTCAGAT
TGCCGCGATCTGTCTGGCGAATGGGGCAACCTGTGCTACGCGCAATGTGAAGGATTTCCAGCACACTGGCGTCGAACTCG
TCGACCCGTGGAATGTGGAAGCGTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12594.36 Da
• Isoelectric Point: 7.0262

>AT241630 WP_105607669.1 NZ_CP095165:608657-608992 [Enterobacter roggenkampii]
MYKDATPTWGLRRDITPCFGARLVQEGHRLHFLANRAGFTGSFSEVQTLQLNEAFPHFVAYLELMLLSCELNPRYAHCVT
LYRNGLTCEADTLGSHGHVYMAIYPSNQVKD

Nucleotide

• Length: 336 bp

>AT241630 NZ_LT996886:c662047-661814 [Tessaracoccus timonensis]
ATGTCTTCCATTATCGTGCGTGGTCTTGATGACCATGTGAAGCAGCAGCTCGCGTCGCGGGCGAAGGAACACGGGCGGTC
CATGGAGGCCGAGGTTGGCGACATCTTGACGAAGGCGGCCCGACGGCCGCACATAGGTGTGGCTCTTCTGGATGTGGCGC
AGGATGTCGGTGGGGTCGATGAGCTGCCGATTCAGGCGCGCGATGATGTCGCACGGGTGGTGGACTTCGAGTGA