Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 277569..278165 Replicon chromosome
Accession NZ_CP095165
Organism Enterobacter roggenkampii strain K475-2

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag MUY30_RS01245 Protein ID WP_023293553.1
Coordinates 277863..278165 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag MUY30_RS01240 Protein ID WP_021242718.1
Coordinates 277569..277856 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY30_RS01235 (MUY30_01235) 275941..277572 + 1632 WP_008503411.1 Na/Pi cotransporter family protein -
MUY30_RS01240 (MUY30_01240) 277569..277856 - 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
MUY30_RS01245 (MUY30_01245) 277863..278165 - 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUY30_RS01250 (MUY30_01250) 278363..279235 + 873 WP_126288990.1 23S rRNA pseudouridine(2604) synthase RluF -
MUY30_RS01255 (MUY30_01255) 279236..279508 - 273 WP_014830263.1 DUF3811 domain-containing protein -
MUY30_RS01260 (MUY30_01260) 279559..280503 - 945 WP_023293551.1 ketopantoate/pantoate/pantothenate transporter PanS -
MUY30_RS01265 (MUY30_01265) 280609..282183 - 1575 WP_069597754.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T241629 WP_023293553.1 NZ_CP095165:c278165-277863 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T241629 NZ_LT996886:c660171-659890 [Tessaracoccus timonensis]
GTGATCAGATCTTTCGGTGACCGTGACACGGAGCTCGTCTGGTTGCGTGAACCGGCACCGCGGATCGATCCGCGGATTCA
CAAGTCGGCGAACCGGAAGTTGCATCTGCTTGATGCTGCGGTGTCGCTCAACTCGCTTCGGGTTCCGCCGGGGAACCGGC
TCGAAGCGTTGAAGGGCGACCGCAGAGGTCAGCACAGCATCCGGATCAACGACCAGTGGCGGATCTGCTTCGTGTGGACC
GAGGCTGGCCCAGAGAATGTAATCATTGAGGACTACCATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT241629 WP_021242718.1 NZ_CP095165:c277856-277569 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp

>AT241629 NZ_LT996886:c659881-659582 [Tessaracoccus timonensis]
ATGACTGAGAAGCTTTACGCGCCGATTCATCCTGGCGAGGTCTTGATGGAGGACTTCATCGAGGGGTTCGGCATCACGCA
GCACAAGCTCGCGGTGTCCATCGGTGTCCCGCCGCGGCGGATTAACGAGATCGTGCACGGCAAGCGGGCCATCACCGCTG
ACACGGCGTTGCGTCTGGGGCGATACTTCGGTGTCGAGCCGCAGTTCTGGCTCACTCTGCAGAGCCGCTATGAGCTTGAG
CTTGCGCAGGAACGTGTGGCCGATCAGGTGGCCGAGATTAAGCCGCTGCAGGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References