Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 170361..170968 Replicon chromosome
Accession NZ_CP095165
Organism Enterobacter roggenkampii strain K475-2

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H0N5B9
Locus tag MUY30_RS00765 Protein ID WP_071993467.1
Coordinates 170361..170546 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A155E9Y3
Locus tag MUY30_RS00770 Protein ID WP_032675741.1
Coordinates 170561..170968 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY30_RS00750 (MUY30_00750) 166793..168331 + 1539 WP_023345218.1 aldehyde dehydrogenase AldB -
MUY30_RS00755 (MUY30_00755) 168328..169290 - 963 WP_008502735.1 LysR family transcriptional regulator -
MUY30_RS00760 (MUY30_00760) 169411..170151 + 741 WP_126288161.1 MipA/OmpV family protein -
MUY30_RS00765 (MUY30_00765) 170361..170546 + 186 WP_071993467.1 type II toxin-antitoxin system HicA family toxin Toxin
MUY30_RS00770 (MUY30_00770) 170561..170968 + 408 WP_032675741.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MUY30_RS00775 (MUY30_00775) 170972..172048 - 1077 WP_032654523.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
MUY30_RS00780 (MUY30_00780) 172394..173089 - 696 WP_032675742.1 L-ribulose-5-phosphate 4-epimerase -
MUY30_RS00785 (MUY30_00785) 173083..173943 - 861 WP_126288160.1 L-ribulose-5-phosphate 3-epimerase -
MUY30_RS00790 (MUY30_00790) 173946..174599 - 654 WP_032654530.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6882.06 Da        Isoelectric Point: 11.2341

>T241628 WP_071993467.1 NZ_CP095165:170361-170546 [Enterobacter roggenkampii]
VKSADVITVLISHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T241628 NZ_LT996886:c657227-656802 [Tessaracoccus timonensis]
GTGATCGTCCTCGACACCAACGTCGTCTCGGAGATCTTTCGGTCCTCGCTGGAGCCTCGTGTTGTCGAGTGGCTTGTGTC
GCTGACGGGTGACGTTGCGATCACGTCTGTCACTCTTGCGGAGTTGCTTGCCGGCGTCCGTAGGCTCCCGGAGGGCCGAT
GCAAGGACGCGCTGGCGTACGGGATTGAGGGAGCGGTAGTGCCGTATCGGGGGAGCCGGTCGGTGCTCGCGTTCGATGCT
GACGCGGCGGAGCGATATGCGGAGGTGCTCGTGTCGCGTGAGGCGGCAGGTGTGCCGGTCAGTATCGCCGACGCTCAGAT
TGCCGCGATCTGTCTGGCGAATGGGGCAACCTGTGCTACGCGCAATGTGAAGGATTTCCAGCACACTGGCGTCGAACTCG
TCGACCCGTGGAATGTGGAAGCGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15010.78 Da        Isoelectric Point: 4.3897

>AT241628 WP_032675741.1 NZ_CP095165:170561-170968 [Enterobacter roggenkampii]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDNALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPG

Download         Length: 408 bp

>AT241628 NZ_LT996886:c657457-657224 [Tessaracoccus timonensis]
ATGTCTTCCATTATCGTGCGTGGTCTTGATGACCATGTGAAGCAGCAGCTCGCGTCGCGGGCGAAGGAACACGGGCGGTC
CATGGAGGCCGAGGTTCGCGACATCTTGACGAAGGCGGCCCGACGGCCGCACATAGGCGTGGCTCTTCTGAATGTGGCGC
AGGATGTCGGTGGGGTCGATGAGCTGCCGATTCAGGCGCGCGATGATGTCGCACGGGTGGTGGACTTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0N5B9

Antitoxin

Source ID Structure
AlphaFold DB A0A155E9Y3

References