Detailed information of TA system TA241625

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3641353..3642016
• Replicon: chromosome
• Accession: NZ_CP095163
• Organism: Edwardsiella anguillarum strain C-5-1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MUN71_RS16950
• Protein ID: WP_034164690.1
• Coordinates: 3641353..3641769 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MUN71_RS16955
• Protein ID: WP_012849755.1
• Coordinates: 3641750..3642016 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUN71_RS16930 (MUN71_16930)	3637283..3639016	-	1734	WP_034164685.1	single-stranded-DNA-specific exonuclease RecJ	-
MUN71_RS16935 (MUN71_16935)	3639021..3639737	-	717	WP_034164686.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MUN71_RS16940 (MUN71_16940)	3639765..3640664	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MUN71_RS16945 (MUN71_16945)	3640816..3641328	+	513	WP_034164689.1	flavodoxin FldB	-
MUN71_RS16950 (MUN71_16950)	3641353..3641769	-	417	WP_034164690.1	protein YgfX	Toxin
MUN71_RS16955 (MUN71_16955)	3641750..3642016	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MUN71_RS16960 (MUN71_16960)	3642365..3643363	+	999	WP_034164692.1	tRNA-modifying protein YgfZ	-
MUN71_RS16965 (MUN71_16965)	3643405..3644229	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MUN71_RS16970 (MUN71_16970)	3644386..3645258	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MUN71_RS16975 (MUN71_16975)	3645867..3646517	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T241625 WP_034164690.1 NZ_CP095163:c3641769-3641353 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLTPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRALLDTGDDRA

Nucleotide

• Length: 417 bp

>T241625 NZ_LT992502:c3868739-3868329 [Enterobacter bugandensis]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGGCTGGTTGCGGC
CATCGTTTTACTCATGCCGTGGCCGCTCAGCTATACGCCGCTGTGGCTGCTATTACTTTCGTTTGTTGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAACGCGCGTCAGGGCGAGATTAAGCTGCTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTCGGTGTACCCTGGATGCTTAACGCCGGGATGATGTTACGGTTACGCAAAGTGGGGGGCGGACGTTG
CCAGCACCTGTGGCTGGCGGCGGACAGTATGGACGCATCAGAATGGCGGGATCTGCGCCGGATGTTGCTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT241625 WP_012849755.1 NZ_CP095163:c3642016-3641750 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT241625 NZ_LT992502:c3868986-3868720 [Enterobacter bugandensis]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGAATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTACGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8