Detailed information of TA system TA241616

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 2024117..2024639
• Replicon: chromosome
• Accession: NZ_CP095163
• Organism: Edwardsiella anguillarum strain C-5-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: MUN71_RS09560
• Protein ID: WP_015871319.1
• Coordinates: 2024117..2024398 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: MUN71_RS09565
• Protein ID: WP_015871318.1
• Coordinates: 2024388..2024639 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUN71_RS09535 (MUN71_09535)	2019518..2019736	+	219	WP_225865175.1	hypothetical protein	-
MUN71_RS09540 (MUN71_09540)	2019898..2020293	+	396	WP_225865176.1	hypothetical protein	-
MUN71_RS09545 (MUN71_09545)	2020286..2021947	+	1662	WP_049703944.1	terminase	-
MUN71_RS09555 (MUN71_09555)	2021944..2024045	+	2102	Protein_1839	portal protein	-
MUN71_RS09560 (MUN71_09560)	2024117..2024398	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MUN71_RS09565 (MUN71_09565)	2024388..2024639	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUN71_RS09570 (MUN71_09570)	2024927..2025418	+	492	WP_225865179.1	hypothetical protein	-
MUN71_RS09575 (MUN71_09575)	2025405..2025752	+	348	WP_144242832.1	hypothetical protein	-
MUN71_RS09580 (MUN71_09580)	2026124..2027998	+	1875	WP_034165826.1	PhoX family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1991417..2038749	47332

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T241616 WP_015871319.1 NZ_CP095163:c2024398-2024117 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T241616 NZ_LT992493:283141-283443 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT241616 WP_015871318.1 NZ_CP095163:c2024639-2024388 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT241616 NZ_LT992493:282896-283153 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3