Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1493993..1495425 Replicon chromosome
Accession NZ_CP095162
Organism Streptococcus suis strain TJS75

Toxin (Protein)


Gene name abiEi Uniprot ID A0A126UMF2
Locus tag MUY23_RS07380 Protein ID WP_024383472.1
Coordinates 1494580..1495425 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A126UN77
Locus tag MUY23_RS07375 Protein ID WP_024401254.1
Coordinates 1493993..1494583 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY23_RS07350 1489111..1491261 - 2151 WP_002935100.1 peptide cleavage/export ABC transporter -
MUY23_RS07355 1491464..1491655 - 192 WP_002935101.1 hypothetical protein -
MUY23_RS07360 1491744..1492016 - 273 WP_002935103.1 DUF3884 family protein -
MUY23_RS07365 1492045..1493361 - 1317 WP_002935107.1 glycosyltransferase family 2 protein -
MUY23_RS07370 1493549..1493710 - 162 WP_002935108.1 agglutinin receptor -
MUY23_RS07375 1493993..1494583 + 591 WP_024401254.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
MUY23_RS07380 1494580..1495425 + 846 WP_024383472.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MUY23_RS07385 1495487..1498288 - 2802 WP_024394478.1 phage tail tip lysozyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32435.11 Da        Isoelectric Point: 5.7531

>T241613 WP_024383472.1 NZ_CP095162:1494580-1495425 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSKEGISFTIQSITAIKESDDYGGYRATILCQIENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFTYRETELDFAKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

>T241613 NZ_LT992493:277510-277797 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23210.76 Da        Isoelectric Point: 7.3107

>AT241613 WP_024401254.1 NZ_CP095162:1493993-1494583 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAIFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVSVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Download         Length: 591 bp

>AT241613 NZ_LT992493:277269-277520 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UMF2

Antitoxin

Source ID Structure
AlphaFold DB A0A126UN77

References