Detailed information of TA system TA241611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-epsilon
• Location: 1209380..1210931
• Replicon: chromosome
• Accession: NZ_CP095162
• Organism: Streptococcus suis strain TJS75

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: MUY23_RS06055
• Protein ID: WP_079739431.1
• Coordinates: 1209380..1210657 (-)
• Length: 426 a.a.

Antitoxin (Protein)

• Gene name: epsilon
• Uniprot ID: R2XCR7
• Locus tag: MUY23_RS06060
• Protein ID: WP_000301765.1
• Coordinates: 1210659..1210931 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUY23_RS06035	1204468..1206279	-	1812	WP_014637055.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
MUY23_RS06040	1206711..1208060	-	1350	WP_053866436.1	ISLre2 family transposase	-
MUY23_RS06045	1208234..1208449	-	216	WP_053866437.1	hypothetical protein	-
MUY23_RS06050	1208496..1209293	-	798	WP_053866438.1	AAA family ATPase	-
MUY23_RS06055	1209380..1210657	-	1278	WP_079739431.1	zeta toxin family protein	Toxin
MUY23_RS06060	1210659..1210931	-	273	WP_000301765.1	antitoxin	Antitoxin
MUY23_RS06065	1210948..1211157	-	210	WP_000527318.1	peptide-binding protein	-
MUY23_RS06070	1211256..1212152	-	897	WP_002334978.1	AAA family ATPase	-
MUY23_RS06075	1212255..1212515	-	261	Protein_1191	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
MUY23_RS06080	1212685..1213422	-	738	WP_012477196.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	-
MUY23_RS06085	1213547..1213642	-	96	WP_001809736.1	23S rRNA methyltransferase attenuation leader peptide	-
MUY23_RS06090	1213718..1214059	-	342	Protein_1194	recombinase family protein	-
MUY23_RS06095	1214411..1214728	-	318	WP_053866439.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B)	-	1206711..1236546	29835
	-	flank	IS/Tn	erm(B)	-	1212685..1217432	4747

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-214)

Antitoxin

• Bacterial epsilon antitoxin (2-90)

Sequences

Toxin

Protein

• Length: 426 a.a.
• Molecular weight: 48802.57 Da
• Isoelectric Point: 9.0764

>T241611 WP_079739431.1 NZ_CP095162:c1210657-1209380 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKANKDRPQLQAMLAYIREGDIVVVTELERLGRNNKELTEVMNDIQAKGATLEVL
NLPTLRGIEDDNLRRLLNNLILELYKYQAQAERERIKERQRQGIAIAKTQGKYKGRKAIFSEDDSRLLHAFDLYLEGLSD
KDVAKLTGINERTFRRYREKHKIKR

Nucleotide

• Length: 1278 bp

>T241611 NZ_LT992493:272218-272550 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10721.25 Da
• Isoelectric Point: 6.4676

>AT241611 WP_000301765.1 NZ_CP095162:c1210931-1210659 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Nucleotide

• Length: 273 bp

>AT241611 NZ_LT992493:272537-272851 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A829F0A3