Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1209380..1210931 Replicon chromosome
Accession NZ_CP095162
Organism Streptococcus suis strain TJS75

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag MUY23_RS06055 Protein ID WP_079739431.1
Coordinates 1209380..1210657 (-) Length 426 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag MUY23_RS06060 Protein ID WP_000301765.1
Coordinates 1210659..1210931 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY23_RS06035 1204468..1206279 - 1812 WP_014637055.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
MUY23_RS06040 1206711..1208060 - 1350 WP_053866436.1 ISLre2 family transposase -
MUY23_RS06045 1208234..1208449 - 216 WP_053866437.1 hypothetical protein -
MUY23_RS06050 1208496..1209293 - 798 WP_053866438.1 AAA family ATPase -
MUY23_RS06055 1209380..1210657 - 1278 WP_079739431.1 zeta toxin family protein Toxin
MUY23_RS06060 1210659..1210931 - 273 WP_000301765.1 antitoxin Antitoxin
MUY23_RS06065 1210948..1211157 - 210 WP_000527318.1 peptide-binding protein -
MUY23_RS06070 1211256..1212152 - 897 WP_002334978.1 AAA family ATPase -
MUY23_RS06075 1212255..1212515 - 261 Protein_1191 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
MUY23_RS06080 1212685..1213422 - 738 WP_012477196.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
MUY23_RS06085 1213547..1213642 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
MUY23_RS06090 1213718..1214059 - 342 Protein_1194 recombinase family protein -
MUY23_RS06095 1214411..1214728 - 318 WP_053866439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) - 1206711..1236546 29835
- flank IS/Tn erm(B) - 1212685..1217432 4747


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 426 a.a.        Molecular weight: 48802.57 Da        Isoelectric Point: 9.0764

>T241611 WP_079739431.1 NZ_CP095162:c1210657-1209380 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKANKDRPQLQAMLAYIREGDIVVVTELERLGRNNKELTEVMNDIQAKGATLEVL
NLPTLRGIEDDNLRRLLNNLILELYKYQAQAERERIKERQRQGIAIAKTQGKYKGRKAIFSEDDSRLLHAFDLYLEGLSD
KDVAKLTGINERTFRRYREKHKIKR

Download         Length: 1278 bp

>T241611 NZ_LT992493:272218-272550 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT241611 WP_000301765.1 NZ_CP095162:c1210931-1210659 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT241611 NZ_LT992493:272537-272851 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References