Detailed information of TA system TA241609

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 887638..888881
• Replicon: chromosome
• Accession: NZ_CP095162
• Organism: Streptococcus suis strain TJS75

Toxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A8D4CZB7
• Locus tag: MUY23_RS04470
• Protein ID: WP_002935066.1
• Coordinates: 887638..888405 (-)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: MUY23_RS04475
• Protein ID: WP_002935067.1
• Coordinates: 888405..888881 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUY23_RS04455	884026..884391	-	366	WP_002935058.1	plasmid mobilization relaxosome protein MobC	-
MUY23_RS04460	884401..884760	-	360	WP_002935059.1	SAG1252 family conjugative relaxosome accessory protein	-
MUY23_RS04465	885095..887602	-	2508	WP_053866460.1	AAA family ATPase	-
MUY23_RS04470	887638..888405	-	768	WP_002935066.1	type II toxin-antitoxin system toxin PezT	Toxin
MUY23_RS04475	888405..888881	-	477	WP_002935067.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
MUY23_RS04480	888951..889241	-	291	WP_002935069.1	hypothetical protein	-
MUY23_RS04485	889291..889680	-	390	WP_002935071.1	DUF5945 family protein	-
MUY23_RS04490	889677..889904	-	228	WP_002935073.1	DUF5965 family protein	-
MUY23_RS04495	889958..891034	-	1077	WP_029187303.1	toprim domain-containing protein	-
MUY23_RS04500	891097..892953	-	1857	WP_001820670.1	recombinase family protein	-
MUY23_RS04505	893008..893271	-	264	WP_000253176.1	hypothetical protein	-
MUY23_RS04510	893271..893501	-	231	WP_001206986.1	PC4/YdbC family ssDNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O)	-	873548..930847	57299

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 28956.86 Da
• Isoelectric Point: 5.6977

>T241609 WP_002935066.1 NZ_CP095162:c888405-887638 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPGQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDGLSTQGYHLLIEGTLRTTQVPRQTAQLLVSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDQIQIYQRDRTCIYDSAIDEGSAAEVLQECLFGKWSKVEEEMV
KESELLLNELLEKNK

Nucleotide

• Length: 768 bp

>T241609 NZ_LT992493:251218-251505 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18273.67 Da
• Isoelectric Point: 4.3971

>AT241609 WP_002935067.1 NZ_CP095162:c888881-888405 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT241609 NZ_LT992493:251516-251833 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA