Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 811861..812347 Replicon chromosome
Accession NZ_CP095162
Organism Streptococcus suis strain TJS75

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag MUY23_RS04095 Protein ID WP_002935012.1
Coordinates 811861..812118 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag MUY23_RS04100 Protein ID WP_002935014.1
Coordinates 812108..812347 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY23_RS04075 807495..808565 + 1071 WP_002935006.1 tyrosine recombinase XerS -
MUY23_RS04080 808635..810143 - 1509 WP_013730362.1 phosphoglucomutase -
MUY23_RS04085 810219..811160 - 942 WP_002935009.1 sensor histidine kinase -
MUY23_RS04090 811157..811822 - 666 WP_009909826.1 response regulator transcription factor -
MUY23_RS04095 811861..812118 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUY23_RS04100 812108..812347 - 240 WP_002935014.1 DUF6290 family protein Antitoxin
MUY23_RS04105 812439..814409 - 1971 WP_002935016.1 FtsX-like permease family protein -
MUY23_RS04110 814410..815162 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
MUY23_RS04115 815179..815562 - 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
MUY23_RS04120 815575..815715 - 141 WP_002935023.1 hypothetical protein -
MUY23_RS04125 815814..816548 - 735 WP_002935025.1 TraX family protein -
MUY23_RS04130 816561..816698 - 138 WP_002935027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T241608 WP_002935012.1 NZ_CP095162:c812118-811861 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T241608 NZ_LT992493:c247460-247143 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT241608 WP_002935014.1 NZ_CP095162:c812347-812108 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT241608 NZ_LT992493:c247721-247479 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References