Detailed information of TA system TA241607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-epsilon
• Location: 765457..767008
• Replicon: chromosome
• Accession: NZ_CP095162
• Organism: Streptococcus suis strain TJS75

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: MUY23_RS03850
• Protein ID: WP_079739431.1
• Coordinates: 765731..767008 (+)
• Length: 426 a.a.

Antitoxin (Protein)

• Gene name: epsilon
• Uniprot ID: R2XCR7
• Locus tag: MUY23_RS03845
• Protein ID: WP_000301765.1
• Coordinates: 765457..765729 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUY23_RS03810	761660..761977	+	318	WP_053866439.1	hypothetical protein	-
MUY23_RS03815	762329..762670	+	342	Protein_739	recombinase family protein	-
MUY23_RS03820	762746..762841	+	96	WP_001809736.1	23S rRNA methyltransferase attenuation leader peptide	-
MUY23_RS03825	762966..763703	+	738	WP_012477196.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	-
MUY23_RS03830	763873..764133	+	261	Protein_742	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
MUY23_RS03835	764236..765132	+	897	WP_002334978.1	AAA family ATPase	-
MUY23_RS03840	765231..765440	+	210	WP_000527318.1	peptide-binding protein	-
MUY23_RS03845	765457..765729	+	273	WP_000301765.1	antitoxin	Antitoxin
MUY23_RS03850	765731..767008	+	1278	WP_079739431.1	zeta toxin family protein	Toxin
MUY23_RS03855	767095..767892	+	798	WP_053866438.1	AAA family ATPase	-
MUY23_RS03860	767939..768154	+	216	WP_053866437.1	hypothetical protein	-
MUY23_RS03865	768328..769677	+	1350	WP_053866436.1	ISLre2 family transposase	-
MUY23_RS03870	770050..770424	+	375	WP_002934959.1	DUF1149 family protein	-
MUY23_RS03875	770426..771277	+	852	WP_002934960.1	DegV family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	erm(B)	-	758956..763703	4747

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-214)

Antitoxin

• Bacterial epsilon antitoxin (2-90)

Sequences

Toxin

Protein

• Length: 426 a.a.
• Molecular weight: 48802.57 Da
• Isoelectric Point: 9.0764

>T241607 WP_079739431.1 NZ_CP095162:765731-767008 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKANKDRPQLQAMLAYIREGDIVVVTELERLGRNNKELTEVMNDIQAKGATLEVL
NLPTLRGIEDDNLRRLLNNLILELYKYQAQAERERIKERQRQGIAIAKTQGKYKGRKAIFSEDDSRLLHAFDLYLEGLSD
KDVAKLTGINERTFRRYREKHKIKR

Nucleotide

• Length: 1278 bp

>T241607 NZ_LT992493:c231719-231420 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10721.25 Da
• Isoelectric Point: 6.4676

>AT241607 WP_000301765.1 NZ_CP095162:765457-765729 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Nucleotide

• Length: 273 bp

>AT241607 NZ_LT992493:c231958-231716 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Structures

Antitoxin

• PDB: 3Q8X
• PDB: 1GVN
• AlphaFold DB: A0A829F0A3