Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1229786..1230412 Replicon chromosome
Accession NZ_CP095161
Organism Avibacterium paragallinarum strain ZJ-C

Toxin (Protein)


Gene name hicA Uniprot ID A0A2S5AWB0
Locus tag LNL76_RS05945 Protein ID WP_017807138.1
Coordinates 1229786..1229968 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2S5AX18
Locus tag LNL76_RS05950 Protein ID WP_017807139.1
Coordinates 1230005..1230412 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNL76_RS05915 1225175..1225321 + 147 WP_165816385.1 hypothetical protein -
LNL76_RS05920 1225308..1225673 + 366 WP_110478434.1 hypothetical protein -
LNL76_RS05925 1225657..1225863 + 207 WP_017807131.1 hypothetical protein -
LNL76_RS05930 1225876..1226154 + 279 WP_035688595.1 hypothetical protein -
LNL76_RS05935 1226176..1228566 + 2391 WP_245148639.1 replication endonuclease -
LNL76_RS05940 1228599..1229144 + 546 WP_035688593.1 phage N-6-adenine-methyltransferase -
LNL76_RS05945 1229786..1229968 + 183 WP_017807138.1 type II toxin-antitoxin system HicA family toxin Toxin
LNL76_RS05950 1230005..1230412 + 408 WP_017807139.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LNL76_RS05955 1230425..1230652 - 228 WP_110478436.1 hypothetical protein -
LNL76_RS05960 1230961..1231218 - 258 WP_110478437.1 ogr/Delta-like zinc finger family protein -
LNL76_RS05965 1231299..1232339 - 1041 WP_245148640.1 phage portal protein -
LNL76_RS05970 1232302..1234140 - 1839 WP_245148684.1 terminase family protein -
LNL76_RS05975 1234320..1235219 + 900 WP_110478439.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6714.92 Da        Isoelectric Point: 11.2162

>T241605 WP_017807138.1 NZ_CP095161:1229786-1229968 [Avibacterium paragallinarum]
VNSANLIKQVEKDGWVLVSVKGSHHQFKHPTKKGRVTIPHPKKDLHIKTVNSILKQAGLK

Download         Length: 183 bp

>T241605 NZ_LT992493:c220009-219740 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14984.09 Da        Isoelectric Point: 4.5312

>AT241605 WP_017807139.1 NZ_CP095161:1230005-1230412 [Avibacterium paragallinarum]
MLYPIGIEMGDEKHAYGVVVPDVPGCFSAGDTLEEAFTNAKEAIAFHIEGMLEDGEEIPLPTDLQRHMQNKEYEGFTFTV
VDVDLTHLMGKAEKINVTLPKILINKIDNYVSTHPQYKSRSGFLAQIATDKLLSA

Download         Length: 408 bp

>AT241605 NZ_LT992493:c220280-220002 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S5AWB0

Antitoxin

Source ID Structure
AlphaFold DB A0A2S5AX18

References