Detailed information of TA system TA241604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 932999..934632
• Replicon: chromosome
• Accession: NZ_CP095161
• Organism: Avibacterium paragallinarum strain ZJ-C

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LNL76_RS04530
• Protein ID: WP_110478934.1
• Coordinates: 933325..934632 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LNL76_RS04525
• Protein ID: WP_110478935.1
• Coordinates: 932999..933325 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNL76_RS04505	928502..929233	+	732	WP_110478938.1	methyltransferase domain-containing protein	-
LNL76_RS04510	929340..931109	+	1770	WP_110478937.1	30S ribosomal protein S12 methylthiotransferase accessory factor YcaO	-
LNL76_RS04515	931244..931666	+	423	WP_110478936.1	DUF1043 family protein	-
LNL76_RS04520	931828..932958	+	1131	WP_017806521.1	class Ia ribonucleoside-diphosphate reductase subunit beta	-
LNL76_RS04525	932999..933325	-	327	WP_110478935.1	helix-turn-helix domain-containing protein	Antitoxin
LNL76_RS04530	933325..934632	-	1308	WP_110478934.1	HipA domain-containing protein	Toxin
LNL76_RS04535	934732..934980	-	249	WP_110478933.1	class I ribonucleotide reductase maintenance protein YfaE	-
LNL76_RS04540	936517..937329	-	813	WP_110478931.1	4-hydroxy-tetrahydrodipicolinate reductase	-
LNL76_RS04545	937344..937979	-	636	WP_110478930.1	LysE family transporter	-
LNL76_RS04550	937991..938491	-	501	WP_110478929.1	phosphatidylglycerophosphatase A	-
LNL76_RS04555	938497..939531	-	1035	WP_110478928.1	thiamine-phosphate kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (158-351)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 50336.30 Da
• Isoelectric Point: 5.9938

>T241604 WP_110478934.1 NZ_CP095161:c934632-933325 [Avibacterium paragallinarum]
MEKLILQTYIDQEWRDMAELHFEKETYQLSNLVYFPDYITQYFGQEGSRAVSINYPVHIFIENRKTLWSCIGDIAPAGAS
RRYWIESLDIKHLPESEQNYRLLKYGAISPVGNLRIKEATPQKTEVRYFDIEKVKDRQSDFLEYANQSGAMVGGATGAGG
EAPKLLLKRHNGKVWIDNLQDGKDQDISYLVKYPRGRYSSIDCDILRAEFHYYQEVAELGFDTIDIHHMCLEEGERYPSL
WLPRFDITKKEGKYNRLALESVYSMLQKQGGTLEHEATIRQLIKIISASNLEFDQQHFVLEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQKIWLAPIYDFAPMRADPEGIIRSTTWNRKGSLPQEFAGEYRFDLIAESLSDLIEPSLLLTKLQQLAIRLVD
LKSRLAQRGVPQAILDHPSIGFDYLPEKLKAWGLV

Nucleotide

• Length: 1308 bp

>T241604 NZ_LT992493:c218109-217612 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12226.42 Da
• Isoelectric Point: 11.1419

>AT241604 WP_110478935.1 NZ_CP095161:c933325-932999 [Avibacterium paragallinarum]
MITRKNASKVGATISTTERNNVRNRIIKALLLGKMTQGQALRKLRIEMLGVNQQQYMKMVKVSRQTLSNIENDKGNYSVA
TINQVFKPFGFELGLVPISKELLTEIMQ

Nucleotide

• Length: 327 bp

>AT241604 NZ_LT992493:c218378-218106 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA