Detailed information of TA system TA241602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 562735..563253
• Replicon: chromosome
• Accession: NZ_CP095161
• Organism: Avibacterium paragallinarum strain ZJ-C

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LNL76_RS02840
• Protein ID: WP_110479438.1
• Coordinates: 563059..563253 (+)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0F5EVQ3
• Locus tag: LNL76_RS02835
• Protein ID: WP_046098946.1
• Coordinates: 562735..563025 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNL76_RS02810	557942..559054	+	1113	WP_110503384.1	porin	-
LNL76_RS02815	559327..560400	+	1074	WP_194742935.1	porin	-
LNL76_RS02820	560623..561501	+	879	WP_194742934.1	porin	-
LNL76_RS02825	561461..561697	+	237	WP_194742933.1	porin	-
LNL76_RS02830	561818..562543	-	726	WP_110479437.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
LNL76_RS02835	562735..563025	+	291	WP_046098946.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LNL76_RS02840	563059..563253	+	195	WP_110479438.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LNL76_RS02845	563341..565119	+	1779	WP_110479439.1	aspartate--tRNA ligase	-
LNL76_RS02850	565189..565794	+	606	WP_226537674.1	hypothetical protein	-
LNL76_RS02855	565921..566310	+	390	WP_110479440.1	hypothetical protein	-
LNL76_RS02860	566273..566731	+	459	WP_110479494.1	dihydroneopterin triphosphate diphosphatase	-
LNL76_RS02865	567016..567756	+	741	WP_194742932.1	YebC/PmpR family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (22-63)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-76)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7532.02 Da
• Isoelectric Point: 9.6862

>T241602 WP_110479438.1 NZ_CP095161:563059-563253 [Avibacterium paragallinarum]
MAKEFKRDLVQLAKKAPHLFVHPLKNNLKGYMDCHILNDLVLIYKIEQQCLKLIRLNTHSEVFA

Nucleotide

• Length: 195 bp

>T241602 NZ_LT992492:2401852-2402175 [Vibrio cholerae]
ATGAGCTGGAAGATCGACTTTTACGATGGCGTTGAGGATCAGATCCTCGATATGCCACCCAAAATACAAGCTCGCATGAT
TAAGCTTTTAGAGCTGATGGAAAAGCATGGTGCAAACTTGGGGCCTCCTCATACTGAGTCTATGGGCGATGGGTTATTTG
AAATCCGCGCCAAAGCTCAAGAAGGTATTGGTAGAGGCTTATTTTGCTACTTAAAAGGGAATCACATTTATGTGTTACAC
GCTTTTGTAAAAAAATCTCAAAAGACGCCCAAAAATGAGCTCAATCTTGCCAGAGATAGACAAAAAGAGGTTCAAAAATC
ATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10652.19 Da
• Isoelectric Point: 4.7185

>AT241602 WP_046098946.1 NZ_CP095161:562735-563025 [Avibacterium paragallinarum]
MTNNNAVVNFRLPQHLKTEAFEVIAQYGLTPSQVFNMFLTEIAATKAIPLSLNYLQPNAKTLAAMNEIESGTAERLSLDD
KTDLATLLQQIAEEKK

Nucleotide

• Length: 291 bp

>AT241602 NZ_LT992492:2402172-2402450 [Vibrio cholerae]
ATGAGTCTGCAAAAACTGAAACAACGTGCTTTAGCCAATGCTGAAGTTAAGAATGAGTACGATAAGCTTGAGAGTGAGTT
CAGCTTTATTGATCAATTGCTTACCATGAGAACAAAGGCAGGACTTACTCAAGAACAAGTTGCTGAAAGAATGCATACCC
AAAAAAGTAATGTCAGTCGTTTAGAAAAAGGTAATGCCAATCCAAGTTGGTCAACTCTTCTAAAATATGCTCACGCATGT
GGCTTTGAACTAACACTCAAGCCACAAAAAATGAGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0F5EVQ3